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NCT07600580RecruitingPhase 4

The Association Between Bilateral Intermediate Cervical Plexus Block During Total Thyroidectomy and Surgical Stress Response

The Association Between Bilateral Intermediate Cervical Plexus Block and Salivary and Serum Biomarkers of Surgical Stress Response During Total Thyroidectomy

Source: ClinicalTrials.gov · Last updated 16 Jun 2026

Brief summary (registry, in English)

The aim of this study is to determine the impact of ultrasound-guided bilateral intermediate cervical plexus block on the surgical stress response in patients undergoing total thyroidectomy, as measured by the concentration of stress and inflammatory biomarkers in the participants' saliva and serum. The study will be conducted on 48 subjects divided into two groups of 24: a control group receiving total intravenous anesthesia (TIVA) and an experimental group receiving TIVA combined with a bilateral intermediate cervical plexus block. Investigators hypothesized that a combination of bilateral intermediate cervical plexus block and total intravenous anesthesia (TIVA) would reduce the surgical stress response, as measured by salivary and blood biomarkers, compared to TIVA alone in patients undergoing total thyroidectomy. Should the research confirm the hypothesis, it will provide an objective scientific argument for including the block in standard anesthetic protocols for total thyroidectomy surgeries, with the ultimate goal of reducing the surgical stress response and ensuring faster patient recovery.

Status (registry)
Recruiting
Phase (registry)
Phase 4
Study type
Interventional
Enrollment
48 (estimated)
First submitted
7 May 2026
Start date
13 May 2024
Primary completion date
3 Feb 2027
Lead sponsor
University Hospital Dubrava
NCT number
NCT07600580

What you commit to

  • Study type: Interventional · Phase 4
  • Planned participants: 48
  • From 13 May 2024 to the primary completion date, 3 Feb 2027
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • hypothyroidism or hyperthyroidism at the time of surgery
  • additional surgical interventions during the procedure
  • history of previous neck surgery or radiation
  • chronic corticosteroid therapy

Other illness

  • infection at the block injection site
  • hypersensitivity or contraindications to the medications used in the study
  • uncontrolled respiratory disease
  • diabetes mellitus
  • autoimmune disease

Other

  • patients who refuse to sign the informed consent form
  • presence of substernal goiter
  • coagulopathy
  • smokers
  • pregnant women.

Who the study is looking for

  • patienets of both sexes
  • 18 years of age and older
  • ASA I or ASA II
  • euthyroid status
  • signed informed consent

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
University Hospital Dubrava
Coordinator of this site? Confirm its status
ZagrebCroatiaRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.