NCT07600710Not yet recruiting
Periodontal Disease in Patients With Lynch Syndrome
Periodontal Disease in Patients With Lynch Syndrome: a Retrospective Observational, Monocentric Case-control Study
Source: ClinicalTrials.gov · Last updated 22 May 2026
Brief summary (registry, in English)
The field of human microbiome research has undergone a revolution in its approach toward understanding how microorganisms influence the physiology of their host 1. The influence of the oral microbiota is not confined to this location 2. Periodontitis is a "chronic inflammatory disease associated with dysbiotic plaque biofilms and characterized by a progressive destruction of the tooth supporting apparatus"3. Given these observations, the central research question of the present study is to determine the prevalence of periodontitis in patients with Lynch syndrome (LS) compared with reference prevalence estimates from the general population40.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 25 (estimated)
- First submitted
- 12 May 2026
- Start date
- 1 Jun 2026
- Primary completion date
- 31 Jul 2026
- Lead sponsor
- Rotundo Roberto
- NCT number
- NCT07600710
What you commit to
- Study type: Observational
- Planned participants: 25
- From 1 Jun 2026 to the primary completion date, 31 Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Subjects affected by systemic, autoimmune, chronic inflammatory, neurological, or severe psychiatric disorders, or by any other clinical condition that may interfere with study participation or data interpretation
- Subjects with systemic conditions known to strongly affect periodontal status (e.g. uncontrolled diabetes, autoimmune inflammatory diseases, ongoing cancer therapy) were excluded to reduce major confounding factors that could independently alter periodontal outcomes.
Age
- Age \< 18 years;
Other
- Absence of sufficient periodontal clinical or radiographic data to establish a periodontal diagnosis;
Who the study is looking for
- Age ≥18 years;
- All sexes eligible
- Established diagnosis of LS performed as part of clinical practice, with a germline pathogenic/likely pathogenic variant in one of the following genes: MLH1, MSH2, MSH6, PMS2, and EpCAM
- LS subjects undergoing surveillance gastrointestinal endoscopy according to clinical practice and international guidelines.
- Subjects underwent dental and periodontal examination
Age in the registry: 18 years to - · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| IRCCS San Raffaele Coordinator of this site? Confirm its status | Milan | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.