NCT07600801Recruiting
LEGACY: Lung Cancer Screening in Individuals With a Lung Cancer Family History-Protocol B
Source: ClinicalTrials.gov · Last updated 25 Aug 2026
Brief summary (registry, in English)
This research is being done to determine if an image-based deep learning model (Sybil) can accurately predict the likelihood of future lung cancer based on chest computed tomography (CT) imaging from individuals with a family history of lung cancer.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 2250 (estimated)
- First submitted
- 14 May 2026
- Start date
- 17 Jun 2026
- Primary completion date
- 31 Dec 2033
- Lead sponsor
- Massachusetts General Hospital
- Diseases
- Lung cancer
- NCT number
- NCT07600801
What you commit to
- Study type: Observational
- Planned participants: 2250
- From 17 Jun 2026 to the primary completion date, 31 Dec 2033
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- \- None
Who the study is looking for
- ≥18 years of age
- Positive family history of lung cancer (defined as):
- Has ≥1 first-degree relative OR
- Has ≥2 second-degree relatives with a diagnosis of non-small cell lung cancer or small cell lung cancer (NB: a first-degree relative = parent, sibling, or child, a second-degree relative = grandparent, blood-related aunt or uncle, grandchild, blood-related niece or nephew, half-sibling)
- Willing to provide images from at least one previously obtained CT Chest scan, if available.
Age in the registry: 18 years to - · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.