NCT07601464Recruiting
Evaluation of Tissue and Circulating microRNA Profiles in Patients With Hepatocellular Carcinoma Subjected to Thermal Ablation
Source: ClinicalTrials.gov · Last updated 22 May 2026
Brief summary (registry, in English)
The main objectives of this research project concern the identification of microRNAs circulating and of serum metabolites predictive of treatment response in patients with early stage hepatocellular carcinoma undergoing locoregional treatment with thermoablation. In addition, the molecular mechanisms involved in reprogramming will be identified metabolic via bioinformatics analysis and pretreatment liver biopsy analysis and analysis of screening on patient-derived primary lines for personalized therapy.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 150 (estimated)
- First submitted
- 3 Apr 2026
- Start date
- 26 Mar 2026
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT07601464
What you commit to
- Study type: Observational
- Planned participants: 150
- From 26 Mar 2026 to the primary completion date, 31 Dec 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of liver transplant.
Other
- Presence of metastatic liver lesions of other origins.
- Severe, uncorrectable coagulopathy, contraindicating liver biopsy (where necessary) or ablative procedure.
- Patient refusal to participate in the study or inability to obtain informed consent.
- Pregnant women.
Who the study is looking for
- Age ≥ 18
- Diagnosis of hepatocarcinoma confirmed by radiology (LIRADS criteria/triphasic diagnostics) or by biopsy.
- Indication for thermoablation treatment (for radiofrequency) based on the judgment of the hepatologist/surgeon.
- Informed consent signed by the patient.
Age in the registry: 18 years to 64 years · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| IRCCS Policlinico di Sant'Orsola Coordinator of this site? Confirm its status | Bologna | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.