NCT07601867Recruiting
Effect of Dapagliflozin on Right Ventricular-Pulmonary Artery Coupling After Off-Pump Coronary Atery Bypass Grafting
Effect of Dapagliflozin on Right Ventricular-Pulmonary Artery Coupling After Off-Pump Coronary Artery Bypass Grafting: a Prospective Single-Center Study
Source: ClinicalTrials.gov · Last updated 17 Jun 2026
Brief summary (registry, in English)
This prospective, single-center observational study evaluates the effect of dapagliflozin 10 mg/day on right ventricular-pulmonary artery coupling measured by the TAPSE/PASP ratio in 72 patients with left ventricular ejection fraction \<50% after off-pump coronary artery bypass grafting (OPCAB). The primary outcome is the change in TAPSE/PASP ratio from 1 month after surgery (before dapagliflozin) to 7 months after surgery (after 6 months of dapagliflozin therapy).
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 72 (estimated)
- First submitted
- 12 May 2026
- Start date
- 1 Jul 2026
- Primary completion date
- 1 May 2028
- Lead sponsor
- Pyatigorsk City Clinical Hospital Number 1
- Diseases
- Heart failure
- NCT number
- NCT07601867
What you commit to
- Study type: Observational
- Planned participants: 72
- From 1 Jul 2026 to the primary completion date, 1 May 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concomitant valve surgery
- Conversion to on-pump during surgery
- Previous CABG or any prior cardiac surgery
- Contraindication to SGLT2 inhibitors
Other illness
- Perioperative myocardial infarction (as defined by the Fourth Universal Definition of MI)
- More than moderate valvular heart disease
Lab values
- Severe chronic kidney disease (eGFR \< 25 mL/min/1.73 m²)
Other
- Emergency or urgent CABG
- Cardiogenic shock
- Persistent atrial fibrillation or atrial flutter at the time of echocardiographic examination)
- Inability to obtain adequate echocardiographic windows
- Pregnancy or breastfeeding
Who the study is looking for
- Age ≥ 18 years
- Elective isolated off-pump coronary artery bypass grafting (OPCAB)
- Left ventricular ejection fraction (LVEF) \< 50% documented on pre-operative echocardiography
- Written informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Pyatigorsk City Clinical Hospital Number 1 Coordinator of this site? Confirm its status | Pyatigorsk | Russia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.