NCT07602400Not yet recruiting
CAROTID ENDATORECTOMY AND GENERAL ANESTHESIA: Assessment and Evaluation of Cerebral Ischemic Damage With Clinical, Laboratory and Imaging Parameters
CAROTID ENDATORECTOMY AND GENERAL ANESTHESIA: Assessment and Evaluation of Cerebral Ischemic Damage With Clinical, Laboratory and Imaging Parameters: a Single-center, Prospective, Randomized, Comparative Clinical Study
Source: ClinicalTrials.gov · Last updated 22 May 2026
Brief summary (registry, in English)
This study is aiming to provide us with information about the neuroprotective effect of two commonly used anesthetic drugs, during carotid endarterectomy. A day before sugery, a brain MRI will be performed as well as a cognitive function assessment test. The day of the surgery each patient will receive anesthesia either by using intravenous anesthetic drug or an inhalation agent and during the intraoperative period, the Anesthesiologist will draw a small amount of blood in three different times in order to measure brain biomarkers. A day after the surgery, a second brain MRI will be performed as well as a second cognitive function assessment test and their results will be compared to the preoperative ones. The study will focus on whether there is a higher incidence of microischemic brain lesions shown in imaging tests or whether cognitive function is impaired postoperative or whether brain biomarkers indicating brain damage are elevayed with any of these drugs and thus conclude which one shows or not a neuroprotective effect, with the condition that no change in the regular anesthesia management was made and no danger was imposed on the patient.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 160 (estimated)
- First submitted
- 5 May 2026
- Start date
- 30 May 2026
- Primary completion date
- Sept 2027
- Lead sponsor
- University Hospital of Patras
- Diseases
- Stroke
- NCT number
- NCT07602400
What you commit to
- Study type: Observational
- Planned participants: 160
- From 30 May 2026 to the primary completion date, Sept 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Cochlear implants
Other illness
- Small cell and non-small cell lung cancer
- Malignant pheochromocytoma
- CNS or NM diseases
- Allergy or contraindication to any anesthetic factor
Age
- Age ≤ 18 years
Other
- Presence of major neurological deficits that will not allow neurological evaluation and performance of the MoCA test
- Claustrophobia and inability to enter the MRI scanner
- Intracranial vascular clips
- Neurostimulation systems
- Pacemaker incompatible for MRI
- Neuroendocrine tumors
- Melanoma
- Seminoma
- Teratoma
- Schizophrenia
- Patient refusal to participate in the study
Who the study is looking for
- Age ≥ 18 years
- ASA 1-4
- For planned carotid endarterectomy
- Absence of major established neurological deficits that would not allow neurological evaluation and performance of the MoCA test
- Patient consent to participate in the study
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.