NCT07604129Not yet recruiting
Transcranial Sonography and Machine Learning for Schizophrenia Identification
Development and Validation of an Early Prediction Model for Schizophrenia Integrating Transcranial Sonography Structural Imaging and Machine Learning
Source: ClinicalTrials.gov · Last updated 22 May 2026
Brief summary (registry, in English)
Schizophrenia is a serious mental illness. Doctors usually diagnose schizophrenia by talking with patients, reviewing symptoms, and using clinical assessment. In early or less typical cases, diagnosis may be difficult. This study will look at whether brain ultrasound information can help doctors identify features related to schizophrenia. The ultrasound scan used in this study is called transcranial sonography. It is a non-invasive scan that uses sound waves to look at brain structures through natural thin areas of the skull. The study will include adults with schizophrenia and adults without a personal or family history of mental disorders. All participants will have a transcranial sonography scan and provide basic clinical information. The researchers will measure brain ultrasound features, including the substantia nigra, raphe nuclei, and third ventricle, and will combine these features with clinical information. The main question is whether a computer model using ultrasound and clinical information can help distinguish adults with schizophrenia from adults without schizophrenia. The model is intended only as a research tool and possible future aid for doctors. It will not replace diagnosis by a psychiatrist and will not change the participant's usual medical care.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 17 May 2026
- Start date
- 15 Jun 2026
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- Taizhou Second People's Hospital
- Diseases
- Schizophrenia
- NCT number
- NCT07604129
What you commit to
- Study type: Observational
- Planned participants: 200
- From 15 Jun 2026 to the primary completion date, 31 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Severe physical disease or neurological disease.
- History of drug or alcohol abuse.
- Comorbid major psychiatric disorder, such as major depressive disorder.
Other
- Inability to complete clinical assessment or transcranial sonography examination.
- Inadequate temporal acoustic window or poor image quality preventing valid transcranial sonography measurements.
- Acute or clinically unstable state that prevents completion of study procedures.
- Refusal or withdrawal of informed consent.
Who the study is looking for
- Schizophrenia group:
- Adults aged 18 to 65 years.
- Diagnosis of schizophrenia according to ICD-10 criteria by a psychiatrist.
- Able to complete clinical assessment and transcranial sonography examination.
- No other severe physical disease, neurological disease, or major psychiatric disorder.
- Written informed consent provided by the participant or legally authorized representative.
- Healthy control group:
- Adults aged 18 to 65 years.
- No personal history of psychiatric disorders.
- No family history of psychiatric disorders.
- No severe physical disease, neurological disease, or major psychiatric disorder.
- Basic demographic characteristics matched as far as possible to the schizophrenia group.
- Able to complete clinical assessment and transcranial sonography examination.
- Written informed consent provided by the participant or legally authorized representative.
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Taizhou Second People's Hospital Coordinator of this site? Confirm its status | Taizhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.