NCT07605039Not yet recruiting
Structural Mechanisms of Dual-Target tDCS in Stroke Hemiparetic Hand
Multimodal MRI-Based Study of the Structural Mechanisms Underlying Interhemispheric Network Reorganization Induced by Dual-Target tDCS in Stroke Hemiparetic Hand
Source: ClinicalTrials.gov · Last updated 22 May 2026
Brief summary (registry, in English)
This is a single-center, randomized, single-blind study investigating the effects of dual-target transcranial direct current stimulation (tDCS) combined with task-oriented functional electrical stimulation on upper limb recovery in patients with non-acute post-stroke hemiplegia. A total of 56 participants will be recruited and randomly assigned (1:1) to the dual M1 tDCS group or sham stimulation group. The intervention is delivered five times per week for four weeks, with 20 sessions in total. Multimodal MRI (T1W, T2W, and DTI) will be used to assess structural and network-level reorganization of sensorimotor pathways, including the corticospinal tract, in response to tDCS. The primary outcome is the Broetz hand function score, evaluated at baseline, post-intervention, and six-month follow-up. Secondary outcomes include Fugl-Meyer Assessment of the upper extremity (FMA-UE) and multimodal MRI-derived measures of white matter integrity. This study aims to elucidate the structural constraints underlying sensorimotor network lateralization and to identify responder and non-responder profiles based on corticospinal tract damage, providing mechanistic insight into individualized tDCS-based neurorehabilitation after stroke.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 56 (estimated)
- First submitted
- 17 May 2026
- Start date
- 6 May 2026
- Primary completion date
- 30 Jun 2028
- Lead sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
- Diseases
- Stroke
- NCT number
- NCT07605039
What you commit to
- Study type: Interventional
- Planned participants: 56
- From 6 May 2026 to the primary completion date, 30 Jun 2028
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of other neurological disorders or substance abuse.
- Unstable conditions or rapidly progressive/malignant diseases, e.g., severe atrial fibrillation.
- Severe skin allergies.
Other
- Any contraindications to MRI.
- Inability to cooperate with basic communication or assessments, such as severe aphasia.
Who the study is looking for
- Diagnosed with stroke according to the "Diagnostic Criteria for Major Cerebrovascular Diseases in China, 2019", confirmed by cranial CT or MRI.
- First-ever unilateral subcortical stroke (involving the corona radiata, basal ganglia, thalamus, internal capsule, etc.).
- Age 30-75 years.
- Right-handed prior to stroke onset.
- Stroke onset ≥ 2 weeks.
- Hemiplegic hand function at Brunnstrom Stage I-III.
- Written informed consent provided by the patient or legally authorized representative.
Age in the registry: 30 years to 75 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.