NCT07605884Not yet recruiting
Denys-Drash Syndrome and Risk of Post-transplant Lymphoproliferative Disorder
Post-transplant Lymphoproliferative Disorder Following Kidney Transplantation in Denys-Drash Syndrome: a Case-control Study
Source: ClinicalTrials.gov · Last updated 26 May 2026
Brief summary (registry, in English)
Denys-Drash syndrome is a rare genetic disorder of childhood characterized by nephrotic syndrome, nephroblastomas, and genital developmental abnormalities. These children present with rapidly progressive renal failure, leading to kidney transplantation at a median age of 3.6 years. In a study of the French cohort of patients with Denys-Drash syndrome, a high risk of lymphoproliferative syndrome was observed (20%). This frequency is significantly higher than in the general transplant population (4%). The aim of the study is to evaluate the risk of post-transplant lymphoproliferative disorder following kidney transplantation in patients with Denys-Drash syndrome compared to patients with kidney transplant patients without Denys-Drash syndrome.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 108 (estimated)
- First submitted
- 20 Apr 2026
- Start date
- Jun 2026
- Primary completion date
- Jun 2027
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- NCT number
- NCT07605884
What you commit to
- Study type: Observational
- Planned participants: 108
- From Jun 2026 to the primary completion date, Jun 2027
- 7 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- History of lymphoproliferative disorder prior to transplantation
Other illness
- Other hematopoietic cancer
- Other genetic disease with a proven increased risk of lymphoproliferative disorder
Who the study is looking for
- Patient must be a minor at the time of kidney transplantation
- Diagnosis of Denys-Drash syndrome (WT1 pathogenic variants in exons 8 or 9) for cases
- Controls: minor patient, kidney transplanted at the same center as the case, immediately before and immediately after the case
- Kidney transplant recipient on immunosuppressants
- Hospital follow-up in a participating center in France
- Regardless of their Epstein-Barr virus status before transplantation
- Between 2000 and 2022
- Holders of parental authority or adult patients informed of the study and not objecting to the processing of medical data for the study
Sex: All · Does not accept healthy volunteers
Sites (7)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hôpital Femme Mère Enfant, Hospices Civils de Lyon Coordinator of this site? Confirm its status | Bron | France | Unknown status |
| CHU de Lille Coordinator of this site? Confirm its status | Lille | France | Unknown status |
| CHU Montpellier Coordinator of this site? Confirm its status | Montpellier | France | Unknown status |
| CHU de Nancy - Hôpitaux de Brabois Coordinator of this site? Confirm its status | Nancy | France | Unknown status |
| Hôpital enfants et adolescents, CHU Nantes Coordinator of this site? Confirm its status | Nantes | France | Unknown status |
| Hopital Necker Enfants Malades Coordinator of this site? Confirm its status | Paris | France | Unknown status |
| Hopital Robert Debre Coordinator of this site? Confirm its status | Paris | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.