NCT07608588Recruiting
Recovery From Post-Stroke Aphasia With rTMS Targeting Left or Right Anterior Temporal Lobe
Recovery From Post-Stroke Aphasia With rTMS Targeting the Anterior Temporal Lobe: Interhemispheric Activation Changes and Lesion-Connectome-Based Predictive Outcomes
Source: ClinicalTrials.gov · Last updated 29 May 2026
Brief summary (registry, in English)
This project aims to tailor repetitive Transcranial Magnetic Stimulation (rTMS) target to the clinical profile of post-stroke aphasia, specifically focusing on lexicosemantic impairments, to enhance recovery. Functional Magnetic Resonance Imaging (fMRI) will provide critical insights into the effects of facilitatory versus inhibitory stimulation on interhemispheric balance. Additionally, this study will generate new data on how lesion localization and brain connectivity influence individual responses to rTMS, explaining variability in treatment efficacy.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 45 (estimated)
- First submitted
- 22 Apr 2026
- Start date
- 15 May 2026
- Primary completion date
- 30 Jul 2027
- Lead sponsor
- University of South Carolina
- Diseases
- Stroke
- NCT number
- NCT07608588
What you commit to
- Study type: Interventional
- Planned participants: 45
- From 15 May 2026 to the primary completion date, 30 Jul 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Contraindications to rTMS (e.g., uncontrolled epilepsy, history of seizures, intracranial ferromagnetic body, cochlear implant, or factors that lower seizure threshold (see Rossi et al., 2021)
- Stroke involving the left ATL
- Severe depression or psychiatric history
- Known neurodegenerative disorders
Other
- Severely impaired auditory comprehension (WAB Comprehension score of 0 or 1)
- Major phonological impairments (defined as \> 2 errors in non-word repetition of one- and two-syllable items on the PALPA, 2)
- Contraindication to MRI
- Illiteracy
- Severe uncorrected visual or hearing impairments
Who the study is looking for
- Right-handedness (assesed using the Edinburgh Handedness Inventory)
- Native English speakers
- Single left hemispheric stroke
- Diagnosis of aphasia and lexicosemantic impairments (e.g., anomia, semantic errors in picture naming or spontaneous speech) confirmed by a Speech and Language Pathologist or Physician
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| McCausland Center Coordinator of this site? Confirm its status | Columbia | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.