NCT07609329Recruiting
Preoperative Immunonutrition in Patients With Bone and Soft Tissue Sarcomas
Effect of Preoperative Immunomodulatory Nutritional Intervention on Postoperative Complications and Sarcopenia in Patients With Bone and Soft Tissue Sarcomas
Source: ClinicalTrials.gov · Last updated 27 May 2026
Brief summary (registry, in English)
This study will evaluate whether a short nutritional intervention before surgery can improve recovery in patients with bone and soft tissue sarcomas. Patients with these tumors often have a higher risk of poor nutrition and loss of muscle mass. These problems may increase the risk of complications after major orthopedic surgery. Participants will be randomly assigned to one of two groups. One group will receive a special oral nutritional supplement twice daily before surgery, in addition to standard care. The other group will receive standard care without the preoperative nutritional supplement. The main aim of the study is to compare the rate of clinically relevant postoperative complications within 30 days after surgery. The study will also evaluate changes in muscle mass on CT scans, blood markers of nutrition and inflammation, nutritional risk, functional status, length of hospital stay, and tolerance of the nutritional supplement.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 13 May 2026
- Start date
- 1 Apr 2026
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- St. Anne's University Hospital Brno, Czech Republic
- Diseases
- Childhood cancers, Sarcoma
- NCT number
- NCT07609329
What you commit to
- Study type: Interventional
- Planned participants: 100
- From 1 Apr 2026 to the primary completion date, 31 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Indication for urgent surgery.
Other illness
- Disseminated disease with more than five metastases.
- Severe hepatic failure.
- Severe renal failure.
Other
- Participants will be excluded if any of the following criteria are present:
- Ongoing parenteral nutrition before study enrollment.
- Inability to receive oral intake.
Who the study is looking for
- Participants must meet all of the following criteria:
- Adult patients aged 18 years or older.
- Histologically confirmed bone sarcoma or soft tissue sarcoma.
- Localized or oligometastatic disease.
- Indicated for planned orthopedic tumor resection.
- Preoperative interval allowing administration of the nutritional intervention for at least 7 days, with 14 days preferred when clinically feasible.
- Ability to receive oral nutritional supplementation.
- Signed informed consent for participation in the study.
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| First Department of Orthopaedic Surgery, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czechia Coordinator of this site? Confirm its status | Brno | Czechia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.