NCT07611136Recruiting
Cerebral Small Vessel Disease Progression Dependent on Stroke Type
Biomarker-based Assessment of Cerebral Small Vessel Disease Progression After Lacunar and Territorial Stroke - a Prospective Cohort Study
Source: ClinicalTrials.gov · Last updated 28 May 2026
Brief summary (registry, in English)
The goal of this prospective, observational study is to understand if cerebral small vessel disease (CSVD) has different velocities and patterns of temporal development, dependent on a concurrent ischemic stroke. It focusses on adult patients with known or newly diagnosed CSVD on magnetic resonance imaging. The study will evaluate if blood based, in parts central nervous system specific protein markers, so called biomarkers, have an additional value reflecting the course of CSVD as defined per MRI assessments. Further patient-relevant endpoints include neuropsychological abilities, neurological functional outcomes, quality of life assessments, stroke recurrence risk.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 180 (estimated)
- First submitted
- 13 Apr 2026
- Start date
- Mar 2026
- Primary completion date
- Apr 2028
- Lead sponsor
- Johannes Dorst
- Diseases
- Stroke
- NCT number
- NCT07611136
What you commit to
- Study type: Observational
- Planned participants: 180
- From Mar 2026 to the primary completion date, Apr 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Alternative plausible causes of white matter hyperintensities other than cerebral small vessel disease (e.g. inflammatory central nervous system disorders, leukodystrophies, brain tumors)
- Known neurodegenerative diseases (e.g. Parkinson's disease, Alzheimer's disease, other dementias)
Other
- Acute or recent traumatic brain injury
- Contraindications to magnetic resonance imaging
- Pregnancy or breastfeeding
- Life expectancy of less than one year
- Inability to comply with study procedures or follow-up visits
Who the study is looking for
- Age ≥ 18 years
- Evidence of cerebral small vessel disease on brain MRI, defined as white matter hyperintensities (Fazekas grade 1-3)
- Assignment to one of the following study groups based on MRI findings:
- cerebral small vessel disease without evidence of an acute ischemic stroke
- cerebral small vessel disease with acute lacunar ischemic stroke
- cerebral small vessel disease with acute territorial ischemic stroke
- Ability to provide written informed consent
- Sufficient German language skills to understand study procedures and assessments
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital Ulm, Department of Neurology, Germany Coordinator of this site? Confirm its status | Ulm | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.