NCT07611201Completed
The Effects of GLP-1 Receptor Agonists on Chemosensory Function and Ingestive Behavior
The Effects of GLP-1 Receptor Agonists on Sensory Systems and Ingestive Behavior
Source: ClinicalTrials.gov · Last updated 28 May 2026
Brief summary (registry, in English)
The goal of this study is to explore whether of GLP-1 receptor agonist use is associated with differences in taste, smell, food preferences, appetite, food cravings, and responses to food cues in adults. The study includes adults who are not currently taking a GLP-1 receptor agonist but may be eligible to use one, and adults who are already taking a GLP-1 receptor agonist as part of their regular medical care for approximately 1 month or approximately 6 months. The main questions it aims to answer are: Are taste and smell function different among adults who are not taking a GLP-1 receptor agonist and adults who have been taking one for different lengths of time? Are food preferences, appetite, food cravings, food reward, attention to food cues, and salivary responses to food cues different among these groups? Researchers will compare adults not currently taking a GLP-1 receptor agonist with adults taking a GLP-1 receptor agonist for approximately 1 month or approximately 6 months. The research team will not prescribe, assign, or provide GLP-1 receptor agonist medications. People in the study will attend two in-person study visits, complete taste and smell tests, complete food preference and computer-based tasks, and provide saliva samples during a food cue task. Questionnaires about appetite, cravings, food cues, and eating behavior will be completed at home over approximately 2 weeks.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 90 (actual)
- First submitted
- 14 May 2026
- Start date
- 20 Feb 2025
- Primary completion date
- 4 May 2026
- Lead sponsor
- Purdue University
- Diseases
- Obesity
- NCT number
- NCT07611201
What you commit to
- Study type: Observational
- Participants enrolled: 90
- From 20 Feb 2025 to the primary completion date, 4 May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous bariatric surgery or planned bariatric surgery within the next year.
Other illness
- Sensitivity or allergy to study foods, taste solutions, odor stimuli, or food-related test materials.
Age
- Younger than 18 years or older than 65 years.
Who the study is looking for
- Ages 18 to 65 years.
- Any sex or gender.
- Body Mass Index (BMI) \>30 kg/m².
- Stable medication use, excluding weight management medications other than GLP-1 receptor agonist use as part of regular medical care.
- Eligible to take GLP-1 receptor agonists but not yet started treatment, or currently taking GLP-1 receptor agonists for weight management for approximately 1 month (±0.5 months) or approximately 6 months (±0.5 months).
- No known sensitivity or allergy to study solutions or foods, including sweet solutions, salty solutions, sour solutions, bitter solutions, fatty stimuli, common food flavors used in testing, milk, and fruit-flavored beverages.
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Purdue University Coordinator of this site? Confirm its status | West Lafayette | United States | Unknown status |
Related publications
- The effects of glucagon-like peptide-1 receptor agonists on chemosensory function and ingestive behavior.Physiol Behav · 2026 · PMID 42641845
This page is information, not medical advice. Discuss any trial with your doctor.