NCT07611487Not yet recruiting
Multimodal MRI Study of Acupuncture's Rapid Antidepressant Mechanisms and Response Prediction in Depression
A Multimodal MRI-Based Study on the Rapid Antidepressant Mechanisms of Acupuncture and Individualized Treatment Response Prediction in Depression
Source: ClinicalTrials.gov · Last updated 7 Oct 2026
Brief summary (registry, in English)
This study aims to investigate the rapid antidepressant effects of acupuncture and to explore the underlying brain mechanisms using multimodal MRI techniques. In addition, the study will evaluate whether individual treatment responses can be predicted based on neuroimaging and clinical data. Participants diagnosed with mild to moderate depression will be enrolled and will receive acupuncture treatment. Depression-related clinical assessment scales and brain imaging data will be collected before and after treatment. The results of this study may help to better understand the mechanisms of acupuncture in rapid antidepressant treatment and support the development of personalized treatment strategies.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- First submitted
- 10 May 2026
- Start date
- 8 Oct 2026
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- Second Affiliated Hospital of Tsinghua University
- Diseases
- Depression
- NCT number
- NCT07611487
What you commit to
- Study type: Interventional
- Planned participants: 80
- From 8 Oct 2026 to the primary completion date, 31 Dec 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who have participated in other clinical drug trials within the past 3 months.
Other illness
- Diagnosis of other major psychiatric disorders or presence of psychotic symptoms.
- History of other severe somatic diseases (e.g., cardiovascular/cerebrovascular diseases, autoimmune diseases), or current/past neurological or organic brain diseases.
- Current or past history of alcohol dependence or abuse of other psychoactive substances.
Other
- Women who are lactating, pregnant, or menstruating.
Who the study is looking for
- Aged 18 to 59 years, and right-handed;
- Patients who have received systematic antidepressant treatment (including antidepressant medications, sedative-hypnotics, electroconvulsive therapy, or transcranial magnetic stimulation) within the 4 weeks prior to enrollment;
- Having a total score on the 17-item Hamilton Depression Rating Scale (HAMD-17) greater than 7 and less than or equal to 24;
- Voluntary participation in the study, with written informed consent provided by the patient themselves or their legally authorized guardian.
Age in the registry: 18 years to 59 years · Sex: All · Accepts healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.