NCT07613307RecruitingPhase 3
A Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes Who Observe Ramadan Fasting
A Phase 3b, Multicenter, Multi-Country, Open-Label, Single-Arm Study to Investigate the Efficacy and Safety of Orforglipron in Adult Participants With Type 2 Diabetes Who Observe Ramadan Fasting (ACHIEVE-RAM)
Source: ClinicalTrials.gov · Last updated 8 Oct 2026
Brief summary (registry, in English)
The purpose of this study is to test the efficacy and safety of orforglipron in participants with T2D (type 2 diabetes) who participate in fasting during Ramadan. For each participant, the study will last up to 48 weeks with a minimum of 7 in clinic visits and 4 virtual visits.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 130 (estimated)
- First submitted
- 22 May 2026
- Start date
- 15 Jul 2026
- Primary completion date
- 31 May 2027
- Lead sponsor
- Eli Lilly and Company
- Diseases
- Type 2 diabetes
- NCT number
- NCT07613307
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 130
- From 15 Jul 2026 to the primary completion date, 31 May 2027
- 40 sites in 4 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have a history of chronic or acute pancreatitis any time prior to screening
Other illness
- Have any form of diabetes other than T2D, including type 1 diabetes (T1D), gestational diabetes, latent autoimmune diabetes, maturity-onset diabetes of the young, and medication-induced diabetes
- Have a family (first-degree relative) or personal history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2.
- Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years.
- Have a history of cholecystectomy (surgically removed gallbladder)
- Have New York Heart Association Functional Classification IV congestive heart-failure.
Other
- Have evidence of a significant, uncontrolled endocrine abnormality, for example, thyrotoxic or adrenal crises, in the opinion of the investigator
Who the study is looking for
- Have a clinical diagnosis of T2D based on the World Health Organization (WHO) classification or other locally applicable diagnostic standards.
- Have an HbA1c value of at least 7.0% (53 millimoles per mole (mmol/mol)) to less than 9.5% (91 mmol/mol) at screening.
- Intend to be compliant with the fast during the Ramadan period.
- Have had stable body weight self-reported change of 5 kilograms (kg) or lower during the 90 days prior to screening.
- Have body mass index (BMI) of 25 kilograms per meter square (kg/m2) or higher at screening.
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (40)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Burjeel Medical City Coordinator of this site? Confirm its status | Abu Dhabi | United Arab Emirates | Not yet recruiting |
| NMC Abu Dhabi Coordinator of this site? Confirm its status | Abu Dhabi | United Arab Emirates | Recruiting |
| NMC Royal hospital Coordinator of this site? Confirm its status | Abu Dhabi | United Arab Emirates | Recruiting |
| Sheikh Khalifa Medical City Coordinator of this site? Confirm its status | Abu Dhabi | United Arab Emirates | Recruiting |
| Tawam Hospital Coordinator of this site? Confirm its status | Al Ain City | United Arab Emirates | Recruiting |
| Dubai Hospital Coordinator of this site? Confirm its status | Dubai | United Arab Emirates | Recruiting |
| Emirates Hospital Dubai Coordinator of this site? Confirm its status | Dubai | United Arab Emirates | Not yet recruiting |
| Sarojini Naidu Medical College Coordinator of this site? Confirm its status | Agra | India | Recruiting |
| Osmania General Hospital Coordinator of this site? Confirm its status | Hyderabad | India | Recruiting |
| Brij Medical Centre Pvt. Ltd. Coordinator of this site? Confirm its status | Kanpur | India | Recruiting |
| Apollo Multispeciality Hospitals limited Coordinator of this site? Confirm its status | Kolkata | India | Recruiting |
| KGN Diabetes and Endocrinology Centre Coordinator of this site? Confirm its status | Mumbai | India | Recruiting |
| Mysore Medical College and Research Institute Coordinator of this site? Confirm its status | Mysore | India | Recruiting |
| Supe Heart & Diabetes Hospital & Research Centre Coordinator of this site? Confirm its status | Nashik | India | Recruiting |
| Diabetes Clinic Coordinator of this site? Confirm its status | Nellore | India | Recruiting |
| Visakha Institute of Medical Sciences Coordinator of this site? Confirm its status | Visakhapatna | India | Recruiting |
| King Abdulaziz University for Health Sciences Ministry of National Guard Health Affairs Coordinator of this site? Confirm its status | Al-Ahsa | Saudi Arabia | Not yet recruiting |
| King Fahad Specialist Hospital Coordinator of this site? Confirm its status | Dammam | Saudi Arabia | Recruiting |
| Imam Abdulrahman bin Faisal University Coordinator of this site? Confirm its status | Dammam | Saudi Arabia | Recruiting |
| National Guard Health Affairs: King Abdulaziz Medical City Coordinator of this site? Confirm its status | Jeddah | Saudi Arabia | Not yet recruiting |
| Dr. Soliman Fakeeh Hospital Coordinator of this site? Confirm its status | Jeddah | Saudi Arabia | Recruiting |
| King Fahad Armed Forces Hospital Jeddah Coordinator of this site? Confirm its status | Jeddah | Saudi Arabia | Not yet recruiting |
| King Abdulaziz University Hospital Coordinator of this site? Confirm its status | Jeddah | Saudi Arabia | Recruiting |
| Osepdale Fatebenefratelli e Oftalmico Coordinator of this site? Confirm its status | Riyadh | Saudi Arabia | Not yet recruiting |
| Dr. Soliman Fakeeh Hospital Coordinator of this site? Confirm its status | Riyadh | Saudi Arabia | Not yet recruiting |
| King Saud University Medical City Coordinator of this site? Confirm its status | Riyadh | Saudi Arabia | Recruiting |
| JOSHA Research Coordinator of this site? Confirm its status | Bloemfontein | South Africa | Recruiting |
| Tiervlei Trial Centre Coordinator of this site? Confirm its status | Cape Town | South Africa | Recruiting |
| Synopsis Research Coordinator of this site? Confirm its status | Cape Town | South Africa | Recruiting |
| TASK Central Coordinator of this site? Confirm its status | Cape Town | South Africa | Recruiting |
| Tread Research Coordinator of this site? Confirm its status | Cape Town | South Africa | Recruiting |
| Synergy Biomed Research Institute (SBRI) Coordinator of this site? Confirm its status | East London | South Africa | Recruiting |
| Aliwal Shoal Medical Centre Coordinator of this site? Confirm its status | eMkhomazi | South Africa | Recruiting |
| Fola Health Coordinator of this site? Confirm its status | Johannesburg | South Africa | Recruiting |
| Trident Clinical Coordinator of this site? Confirm its status | Kimberley | South Africa | Recruiting |
| Ubuntu Clinical Research Krugersdorp Coordinator of this site? Confirm its status | Krugersdorp | South Africa | Recruiting |
| Drs H & V Makan Centre for Diabetes Coordinator of this site? Confirm its status | Lenasia | South Africa | Recruiting |
| Be Part Research (PTY) LTD Coordinator of this site? Confirm its status | Paarl | South Africa | Recruiting |
| Emmed Research Coordinator of this site? Confirm its status | Pretoria | South Africa | Recruiting |
| Dr JM Engelbrecht Trial Site Coordinator of this site? Confirm its status | Somerset West | South Africa | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.