NCT07613489Active, not recruiting
Photobiomodulation for Diabetic Peripheral Neuropathy
Effectiveness of Photobiomodulation Therapy in Enhancing Nerve Function and Quality of Life Among Patients With Diabetic Peripheral Neuropathy: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 23 Jun 2026
Brief summary (registry, in English)
Diabetic peripheral neuropathy (DPN) is a common complication of long-term diabetes, affecting approximately 50 percent of patients. It causes tingling, numbness, and burning pain primarily in the feet, which reduces quality of life. Photobiomodulation therapy (PBMT), also known as low-level laser therapy, is a non-invasive treatment that may improve nerve function by reducing inflammation and promoting cellular repair. This randomized controlled trial aims to evaluate the effectiveness of PBMT in improving nerve function and quality of life in patients with DPN. A total of 36 participants with type 2 diabetes and DPN will be randomly assigned to either a treatment group receiving PBMT (900 nm wavelength, 25W, 1000 Hz frequency) or a control group receiving sham laser therapy. The intervention will be applied to the dorsum and plantar surface of the foot every other day for 6 weeks. Outcomes include pain intensity measured by the Numeric Pain Rating Scale, Neuropathic pain measured by Leeds Assessment of Neuropathic symptoms and signs scale, Nerve function measured by Michigan Neuropathy Screening Instrument and quality of life measured by the NORFOLK QOL DN questionnaire, assessed at baseline and after the intervention period.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 36 (actual)
- First submitted
- 21 May 2026
- Start date
- 1 Feb 2026
- Primary completion date
- 24 Jun 2026
- Lead sponsor
- University of Faisalabad
- Diseases
- Type 2 diabetes
- NCT number
- NCT07613489
What you commit to
- Study type: Interventional
- Participants enrolled: 36
- From 1 Feb 2026 to the primary completion date, 24 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Chronic alcohol or drug abuse
Other illness
- Skin lesions, infections, or ulcers in the treatment area
- Severe heart disease or kidney dysfunction
- Mental illness or malignant tumors
- Post-surgical cases (heart or brain surgery) within 30 days
- History of stroke
Other
- Presence of pacemaker or implanted electrical device
- Patients unwilling to provide informed consent
- Pregnancy
Who the study is looking for
- Diagnosis of type 2 diabetes mellitus
- Diagnosis of diabetic peripheral neuropathy
- Age 18 years or older
- Male and female participants
- Pain duration of 6 months or more
- Numeric Pain Rating Scale (NPRS) score of 3 or greater out of 10 at baseline
- No acute infections at the time of enrollment
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The University of Faisalabad Coordinator of this site? Confirm its status | Faisalābad | Pakistan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.