NCT07613918Recruiting
Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill Children
Transcranial Doppler Assessment of Cerebral Autoregulation and Blood Flow Velocity Patterns in Critically Ill Children: A Prospective Observational Study
Source: ClinicalTrials.gov · Last updated 27 Aug 2026
Brief summary (registry, in English)
This study uses a non-invasive (external) ultrasound test called Transcranial Doppler (TCD) to measure how blood flows through the major arteries of the brain of children receiving care in the Pediatric Intensive Care Unit (PICU). TCD is already used for clinical reasons in many children, but it is not part of routine monitoring for every critically ill child. By using TCD, the investigators hope to better understand how brain blood flow changes during illness. They will also track children's functional status from before their illness to the time of PICU discharge to explore how brain blood flow patterns relate to neurological outcomes.125 participants will be enrolled and will be on study while in the PICU, estimated to be 3-14 days.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 125 (estimated)
- First submitted
- 21 May 2026
- Start date
- 3 Aug 2026
- Primary completion date
- May 2028
- Lead sponsor
- University of Wisconsin, Madison
- NCT number
- NCT07613918
What you commit to
- Study type: Observational
- Planned participants: 125
- From 3 Aug 2026 to the primary completion date, May 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patient with known chronic hypertension
Other
- Subjects with a known or obvious anatomic barrier preventing safe application of the transcranial Doppler probe (e.g., cranial dressings, cranial fixation hardware, ventricular access devices positioned over insonation sites, or bilateral craniectomies)
- Admission FSS score \> 16
- Tracheostomized patient
- The designated sub-investigator (Dr. Talal Al Hendawi) and PI (Dr. Neil Munjal) are unavailable to perform the Transcranial Doppler scan at the time of eligibility. All study scans are performed by either Dr. Al Hendawi or Dr.Munjal to ensure standardization and data integrity. Therefore, if they are unavailable (e.g., due to clinical service, leave, or other scheduling constraints), the patient will not be enrolled in the study.
- Not suitable for study participation due to other reasons at the discretion of the investigators
Who the study is looking for
- Has at least one Parent or Legal Guardian who is willing and able to provide informed consent in English
- Mechanically ventilated (Endotracheal tube)
- Indwelling arterial catheter
- Current patient in the American Family Children's Hospital PICU.
- 1 day to 17.5 years of age
Age in the registry: 1 day to 17 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| American Family Children's Hospital PICU Coordinator of this site? Confirm its status | Madison | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.