NCT07616921Recruiting
A Home-Based Exercise Intervention (CAREFit-BMT) in Improving Heart Function Among Patients With High Risk Acute Myeloid Leukemia Undergoing Stem Cell Transplant
CAREFit-BMT Program to Improve Cardiac Reserve in High-Risk Acute Myeloid Leukemia Patients Preparing to Undergo Allogeneic Hematopoietic Stem Cell Transplantation
Source: ClinicalTrials.gov · Last updated 29 Oct 2026
Brief summary (registry, in English)
This clinical trial studies how well a home-based exercise intervention called Cardiorespiratory Fitness in Bone Marrow Transplant Program (CAREFit-BMT) works in improving heart function among patients with high risk acute myeloid leukemia (AML) undergoing stem cell transplant. Older adults and those with other medical conditions are at a higher risk for complications in the heart and blood vessels (cardiovascular). Older age at transplantation has been associated with nearly all cardiovascular complications occurring after stem cell transplant. This is likely explained by the structural and functional changes that occur in aging hearts as well as the larger burden of cardiovascular risk factors such as diabetes, high blood pressure, and obesity. CAREFit-BMT is a "prehabilitation" program, or exercise initiated prior to intensive therapy, that consists of aerobic exercises and strength training. CAREFit-BMT may be able to increase the likelihood of safe and successful transition to stem cell transplant in patients with high risk AML.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 15 May 2026
- Start date
- 1 Dec 2026
- Primary completion date
- 3 Apr 2028
- Lead sponsor
- University of Washington
- Diseases
- Acute myeloid leukemia
- NCT number
- NCT07616921
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 1 Dec 2026 to the primary completion date, 3 Apr 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Orthopedic, neurologic, or other problems that prevent safe ambulation and protocol adherence. Information on prior falls and other recent orthopedic or neurologic problems will be used to make judgment about protocol eligibility
Other illness
- Recurrence of AML or diagnosis of other invasive cancer
- History of severe aortic stenosis
- New York Heart Association (NYHA) class IV heart failure
Lab values
- Severe anemia (hemoglobin \< 7 gm/dl)
Other
- Severe pain with basic movement
- Pregnant persons
- Unable to give consent
Who the study is looking for
- Age 18 years or older
- Ability to understand and willingness to sign a written informed consent document
- New diagnosis of acute myeloid leukemia at Fred Hutch
- High-risk patients as defined by one, or more, of the following criteria:
- Age 65 years or older and/or
- Hematopoietic Cell Transplantation-Comorbidity Index (HCT-CI) score ≥ 3 (for patients 20 years old or older) and/or
- CARE-BMT score ≥ 5
- Note: HCT-CI and CARE-BMT scores will be measured at pre-screening by study staff
- Able to exercise at low to moderate intensity, as evaluated by study staff
- Access to a mobile smart phone
- Able to read and write in English
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fred Hutch/University of Washington Cancer Consortium Coordinator of this site? Confirm its status | Seattle | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.