NCT07617311Not yet recruiting
Effect of NMES on Spasticity
The Effect of Neuromuscular Electrical Stimulation on Spasticity: A Single-Subject Experimental Study
Source: ClinicalTrials.gov · Last updated 3 Jun 2026
Brief summary (registry, in English)
The goal of this clinical trial is to learn if neuromuscular electrical stimulation (NMES) works to treat spasticity in adult patients with spasticity related to stroke. The main question it aims to answer is: • Does NMES reduces the severity of spasticity? Researchers will compare NMES treatment to baseline and non-stimulation periods to see if NMES works to treat spasticity. Participants will: • first undergo an initial assessment at 10-minute intervals for one hour, followed by 20 minutes of NMES exposure, and subsequent post-treatment assessments at 10-minute intervals for two hours. This daily procedure will be repeated over four days for one patient, and performed only once for the remaining three patients.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 4 (estimated)
- First submitted
- 25 May 2026
- Start date
- 15 Jun 2026
- Primary completion date
- 16 Mar 2028
- Lead sponsor
- Izmir Katip Celebi University
- Diseases
- Stroke
- NCT number
- NCT07617311
What you commit to
- Study type: Interventional
- Planned participants: 4
- From 15 Jun 2026 to the primary completion date, 16 Mar 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concomitant wrist contracture or pain sufficient to impede clinical evaluation
- Non-stable dosage of antispastic medications within the 2 weeks prior to baseline
- Initiation of medications affecting nerve conduction (e.g., antidepressants, anticonvulsants, anesthetics) within the past month; patients on a stable dose for \>1 month remain eligible
Other illness
- Contraindications to neuromuscular electrical stimulation (e.g., active electronic implants, history of epilepsy, or localized skin lesions preventing electrode placement)
- History of neurolytic procedures targeting spasticity in the affected limb.
- History of orthopedic or neurological surgery targeting spasticity in the affected limb
- Cognitive impairment severe enough to compromise adherence to study protocols
Age
- Age \<18 or \>70 year
Other
- Structural abnormalities of the elbow joint obstructing median nerve stimulation
- Median nerve neuropathy or injury in the ipsilateral upper extremity.
- Botulinum toxin infiltration in the target spastic muscles within the preceding 3 months
- Inability to maintain the required testing positions for the upper extremity joints (shoulder, elbow, forearm, and wrist)
- Pregnancy
Who the study is looking for
- Age between 18 and 70 years
- Post-stroke wrist flexor spasticity scored as Grade 2 or 3 on the Australian Spasticity Assessment Scale (ASAS), specifically selecting patients whose passive stretch resistance (post-catch response) can be easily overcome to ensure accurate and unconfounded electrophysiological evaluation.
- Provision of voluntary, written informed consent prior to study enrollment.
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Izmir Katip Çelebi University Coordinator of this site? Confirm its status | Izmir | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.