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NCT07617376RecruitingPhase 4

Pre-discharge Influenza Vaccination in Patients Hospitalized for Acute Cardiac Conditions

Source: ClinicalTrials.gov · Last updated 1 Jun 2026

Brief summary (registry, in English)

Patients hospitalized for acute cardiac conditions-including acute myocardial infarction, acute heart failure, pulmonary embolism, arrhythmias, and hypertensive emergencies-represent a heterogeneous population at very high risk of recurrent cardiovascular events. Influenza infection may act as a trigger for adverse cardiovascular events. Given the persistently low influenza vaccination uptake despite evidence-based benefits observed in vulnerable populations, including patients with cardiac conditions, new strategies to improve vaccination coverage are being explored. Recently, increasing attention has been directed toward an approach already used in fields such as neonatology, where vaccinations are administered prior to hospital discharge. In this investigator-initiated, single-center, randomized, open-label interventional study, we will evaluate whether influenza vaccination administered within 24 hours before hospital discharge in patients hospitalized for acute cardiac conditions is safe and effective in reducing subsequent infections, cardiovascular events, and mortality during the 6 months following hospitalization.

Status (registry)
Recruiting
Phase (registry)
Phase 4
Study type
Interventional
Enrollment
400 (estimated)
First submitted
20 May 2026
Start date
12 Nov 2025
Primary completion date
31 Dec 2026
Lead sponsor
Wroclaw Medical University
NCT number
NCT07617376

What you commit to

  • Study type: Interventional · Phase 4
  • Planned participants: 400
  • From 12 Nov 2025 to the primary completion date, 31 Dec 2026
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Antibiotic therapy to be continued after discharge.

Other illness

  • History of a severe adverse reaction to influenza vaccination,
  • Allergy to any component of the vaccine to be administered,

Other

  • Discharge to another hospital for continuation of treatment or discharge to a long-term care facility,

Who the study is looking for

  • Acute cardiac hospitalization,
  • Planned discharge home within the next 48 hours following completion of in-hospital treatment,
  • No prior influenza vaccination for the current influenza season.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Jan Mikulicz Radecki University Hospital in Wroclaw
Coordinator of this site? Confirm its status
WroclawPolandRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.