NCT07618234Completed
Dermocosmetic Evaluation of Propolis Ointments in Atopic-Prone Dry Skin
Comparative Dermocosmetic Evaluation of Crude Propolis and Ethanolic Extract of Propolis Ointments in Subjects With Atopic-Prone Dry Skin: An Exploratory Randomized Double-Blind Vehicle-Controlled Parallel-Group Study
Source: ClinicalTrials.gov · Last updated 8 Oct 2026
Brief summary (registry, in English)
The goal of this clinical trial is to learn if propolis ointments work to improve dry, atopic-prone skin in adults. Propolis is a natural substance made by honeybees. It will also learn about the safety of these ointments. The main questions it aims to answer are: Does propolis ointment lower dryness, scaling, and roughness better than a base ointment with no propolis? Is there a difference between crude propolis and ethanolic extract of propolis (EEP)? Researchers will compare three ointments to see if they improve skin condition: A propolis ointment made with 3% ethanolic extract A propolis ointment made with 5% crude propolis A base ointment with no propolis (look-alike) Participants will: Apply the ointment to dry skin areas twice a day for 4 weeks Visit the clinic 4 times: for screening, at the start, at week 2, and at week 4 Have their skin checked by a researcher using a standard dryness score Answer questions about skin comfort, itching, and satisfaction Have a patch test before starting to check for allergy to propolis
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 30 (actual)
- First submitted
- 25 May 2026
- Start date
- 15 Apr 2026
- Primary completion date
- 24 May 2026
- Lead sponsor
- Manara University
- Diseases
- Atopic dermatitis (eczema)
- NCT number
- NCT07618234
What you commit to
- Study type: Interventional
- Participants enrolled: 30
- From 15 Apr 2026 to the primary completion date, 24 May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Recent use of systemic corticosteroids (within 2 weeks)
- Recent use of topical corticosteroids (within 1 week)
- Recent use of topical calcineurin inhibitors (within 1 week)
Other illness
- Known allergy to propolis, honey, or bee products
- Known allergy to lanolin
- Acute eczema flare, infected dermatitis, psoriasis, seborrheic dermatitis, fungal infections, herpes simplex, or scabies
- Severe systemic diseases not under control
Other
- Pregnancy or breastfeeding
- Recent use of immunosuppressants (within 4 weeks)
- Recent use of biologics (within 3 months)
- Recent phototherapy (within 2 weeks)
- Poor compliance or inability to cooperate
- Use of other skin products during the study period
Who the study is looking for
- Adults aged 18-60 years
- Atopic-prone dry skin or mild xerotic skin condition
- Mild-to-moderate skin dryness, scaling, roughness, and mild itching
- No acute inflammatory skin disease
- Ability to attend follow-up visits and comply with application instructions
- Signed informed consent form
Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Manara University, Faculty of Pharmacy Coordinator of this site? Confirm its status | Latakia | Syria | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.