NCT07618767Active, not recruiting
A Computational Neuroscience Perspective on the Shared Social Cognitive Deficits of Autism and Schizophrenia
Source: ClinicalTrials.gov · Last updated 8 Jun 2026
Brief summary (registry, in English)
This retrospective cohort study will examine shared neural mechanisms of social cognitive deficits in adults with autism spectrum disorder and adults with schizophrenia using existing clinical, behavioral, and neuroimaging data from National Taiwan University Hospital cohort studies. The study will include adults with autism spectrum disorder, adults with schizophrenia, and healthy control participants. Resting-state functional magnetic resonance imaging (MRI) and structural MRI data will be analyzed to estimate default mode network functional transition indices. These indices will be compared between diagnostic groups and examined in association with social cognitive and psychiatric symptom measures, including the Social Responsiveness Scale (SRS) and the Positive and Negative Syndrome Scale (PANSS) when applicable. No new participants will be recruited, and no intervention will be administered. The study will use previously collected data from 80 adults with autism spectrum disorder, 79 adults with schizophrenia, and 108 healthy controls.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 267 (actual)
- First submitted
- 24 May 2026
- Start date
- 30 Sept 2025
- Primary completion date
- 23 Jul 2026
- Lead sponsor
- National Taiwan University Hospital
- Diseases
- Schizophrenia, Autism
- NCT number
- NCT07618767
What you commit to
- Study type: Observational
- Participants enrolled: 267
- From 30 Sept 2025 to the primary completion date, 23 Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Healthy controls with documented major psychiatric or neurodevelopmental disorders, if identified in source cohort records.
Other
- Missing or incomplete MRI data.
- Poor-quality MRI data due to severe artifacts, failed preprocessing, failed registration, or incomplete brain coverage.
- Excessive head motion during resting-state fMRI that prevents reliable analysis.
- Missing essential demographic or diagnostic information.
- Missing required clinical or behavioral measures for specific association analyses.
Who the study is looking for
- Previously enrolled in one of the source cohort studies approved by the institutional review board of National Taiwan University Hospital.
- Adult participants belonging to one of the following groups:
- Autism spectrum disorder group: participants with a clinical diagnosis of autism spectrum disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria.
- Schizophrenia group: participants with a clinical diagnosis of schizophrenia according to DSM-5 criteria.
- Healthy control group: participants without a history of autism spectrum disorder, schizophrenia, or other major psychiatric or neurodevelopmental disorders according to available source cohort records.
- Availability of resting-state functional MRI data acquired under the study MRI protocol.
- For participants in the autism spectrum disorder group, availability of autistic trait or social functioning measures, such as the Social Responsiveness Scale, when used in symptom-association analyses.
- For participants in the schizophrenia group, availability of psychiatric symptom measures, such as the Positive and Negative Syndrome Scale, when used in symptom-association analyses.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| National Taiwan University Hospital Coordinator of this site? Confirm its status | Taipei | Taiwan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.