NCT07619664Not yet recruiting
High-Intensity Interval Training vs Moderate-Intensity Continuous Training in Phase II Cardiac Rehabilitation
Effects of High-Intensity Interval Training vs Moderate-Intensity Continuous Training on Ejection Fraction, Functional Capacity, and Lipid Profiles in Phase II Cardiac Rehabilitation
Source: ClinicalTrials.gov · Last updated 2 Jun 2026
Brief summary (registry, in English)
This randomized controlled trial aims to compare the effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) in patients undergoing Phase II cardiac rehabilitation after coronary artery disease or post-angioplasty. A total of 66 participants will be randomly allocated into two groups: HIIT (n=33) and MICT (n=33). The intervention will be conducted 3 times per week using treadmill-based exercise protocols under heart rate monitoring. Primary outcomes include changes in left ventricular ejection fraction, functional capacity measured by 6-minute walk test, and lipid profile parameters before and after intervention. Secondary assessment includes health-related quality of life (HRQoL). The study aims to determine which exercise modality provides superior cardiovascular and functional improvement in stable cardiac patients during supervised rehabilitation.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 66 (estimated)
- First submitted
- 2 Apr 2026
- Start date
- Jun 2026
- Primary completion date
- Aug 2026
- Lead sponsor
- Riphah International University
- Diseases
- Coronary artery disease
- NCT number
- NCT07619664
What you commit to
- Study type: Interventional
- Planned participants: 66
- From Jun 2026 to the primary completion date, Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Unstable angina or recent myocardial infarction (within the past 6 weeks).
- Uncontrolled hypertension (systolic BP \>180 mmHg or diastolic BP \>110 mmHg).
- Severe valvular heart disease, arrhythmias, or left ventricular dysfunction (EF \<35%).
- Musculoskeletal disorders (e.g., severe osteoarthritis, recent fractures, or surgeries) preventing safe participation in exercise.
- Neurological disorders affecting mobility or safe exercise (e.g., stroke, Parkinson's disease).
- Any other condition judged by the investigator to make participation unsafe.
Lab values
- Uncontrolled diabetes mellitus (HbA1c \>9% or recent hypoglycemia).
Who the study is looking for
- Adults aged 18-60 years.
- Diagnosed with stable coronary artery disease confirmed by angiography, stress testing, or echocardiography.
- Left ventricular ejection fraction ≥45%.
- Functional NYHA Class I or II.
- Medically cleared by a cardiologist to participate in exercise (including recent ECG or stress test if necessary).
- Lightly active lifestyle prior to study (not involved in structured exercise programs).
Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ch Pervaiz Elahi institute of cardiology Multan. Coordinator of this site? Confirm its status | Multan | Pakistan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.