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NCT07620392RecruitingPhase 2

An Extension Study to Assess Long-Term Safety and Efficacy of Afimkibart in Participants With Rheumatoid Arthritis

An Extension Study to Evaluate the Long-term Safety and Efficacy of Afimkibart (RO7790121) in Patients With Rheumatoid Arthritis Who Participated in Previous Afimkibart Clinical Trials

Source: ClinicalTrials.gov · Last updated 16 Oct 2026

Brief summary (registry, in English)

The study will evaluate the long-term safety and efficacy of Afimkibart (also known as RO7790121) in participants with moderate to severe Rheumatoid Arthritis (RA) who have an inadequate response or intolerance to tumor necrosis factor (TNF) and/or Janus kinase (JAK) inhibitors, and who were previously treated with Afimkibart.

Status (registry)
Recruiting
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
120 (estimated)
First submitted
27 May 2026
Start date
3 Jun 2026
Primary completion date
8 Jul 2033
Lead sponsor
Hoffmann-La Roche
NCT number
NCT07620392
EU CT number
2025-523579-47-00

What you commit to

  • Study type: Interventional · Phase 2
  • Planned participants: 120
  • From 3 Jun 2026 to the primary completion date, 8 Jul 2033
  • 35 sites in 9 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Any permanent discontinuation of study drug in parent study
  • Use of a prohibited therapy during the parent study
  • Evidence of any new or uncontrolled concomitant disease that, in the investigator's judgment, would preclude participant participation in the trial

Other

  • Withdrawal of consent and/or premature discontinuation from parent study

Who the study is looking for

  • Completed the treatment period of the parent study
  • Agreement to adhere to the contraception requirements
  • Continued to be evaluated at the follow-up visit of the parent study and achieved improvement in the SJC66/TJC68 relative to baseline

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (35)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Hopital Erasme
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AnderlechtBelgiumRecruiting
UZ Leuven
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LeuvenBelgiumRecruiting
Centro Mineiro de Pesquisa - CMiP
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Juiz de ForaBrazilRecruiting
Staedtisches Klinikum Dresden
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DresdenGermanyRecruiting
St. Elisabeth Gruppe GmbH Katholische Kliniken Rhein-Ruhr
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HerneGermanyRecruiting
Region Hovedstaden
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FrederiksbergDenmarkRecruiting
Region Sjaelland
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KoegeDenmarkRecruiting
Complexo Hospitalario Universitario A Coruña
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A CoruñaSpainRecruiting
Hospital Universitari Vall d'Hebron
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BarcelonaSpainRecruiting
Hospital Universitario Reina Sofia
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CórdobaSpainRecruiting
Hospital General Universitario Gregorio Marañón
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MadridSpainRecruiting
Hospital Universitario Regional de Málaga
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MálagaSpainRecruiting
Complexo Hospitalario Universitario De Santiago
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Santiago de CompostelaSpainRecruiting
Hospital Universitario Virgen De La Macarena
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SevillaSpainRecruiting
Hospital Quironsalud Infanta Luisa
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SevillaSpainRecruiting
Centre Hospitalier Regional De Marseille
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MarseilleFranceRecruiting
Centre Hospitalier Universitaire De Montpellier
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Montpellier Cedex 5FranceRecruiting
Assistance Publique Hopitaux de Paris
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ParisFranceRecruiting
Les Hopitaux Universitaires De Strasbourg
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Strasbourg Cedex 2FranceRecruiting
Centre Hospitalier Universitaire de Toulouse
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ToulouseFranceRecruiting
Azienda Ospedaliera di Padova
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PadovaItalyRecruiting
Azienda USL IRCCS di Reggio Emilia
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Reggio EmiliaItalyRecruiting
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
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RomeItalyRecruiting
Humanitas Mirasole S.p.A.
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RozzanoItalyRecruiting
BIF-MED
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BytomPolandRecruiting
Centrum Kliniczno-Badawcze J.Brzezicki B.Gornikiewicz-Brzezicka Lekarze sp.p.
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ElblagPolandRecruiting
Reumed Sp. z o.o.
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LublinPolandRecruiting
Twoja Przychodnia Nowosolskie Centrum Medyczne Sp. z o.o.
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Nowa SolPolandRecruiting
Klinika Reuma Park Sp. z o.o. S.K.
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WarsawPolandRecruiting
Reumatop Grzegorz Rozumek Karin Pistorius Sp. j.
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WroclawPolandRecruiting
Rheumatic Disease Center
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GlendaleUnited StatesRecruiting
Accurate Clinical Management LLC
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HoustonUnited StatesRecruiting
Accurate Clinical Research, Inc
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Lake CharlesUnited StatesRecruiting
Arthritis and Rheumatic Disease Specialty Inc
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TamaracUnited StatesRecruiting
DM Clinical Research at Tomball
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TomballUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.