NCT07624071RecruitingPhase 1
A Study to Evaluate ALN-6222 in Participants With Obesity
A Phase 1, Randomized, Double-blind, Placebo-controlled Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of ALN-6222 in Adult Participants With Obesity
Source: ClinicalTrials.gov · Last updated 21 Oct 2026
Brief summary (registry, in English)
This is a first in human, randomized, double-blind (DB), placebo-controlled, single ascending dose (SAD), Phase 1 study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and efficacy of ALN-6222 administered subcutaneously (SC) in adult participants with obesity.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 88 (estimated)
- First submitted
- 29 May 2026
- Start date
- 4 Jun 2026
- Primary completion date
- 14 Dec 2027
- Lead sponsor
- Alnylam Pharmaceuticals
- Diseases
- Obesity
- NCT number
- NCT07624071
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 88
- From 4 Jun 2026 to the primary completion date, 14 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Has known human immunodeficiency virus (HIV) infection; or known current or chronic hepatitis C virus or hepatitis B virus infection
Lab values
- Has alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \>1.5 times the upper limit of normal (ULN)
- Has an estimated glomerular filtration (eGFR) of \<60 mL/min/1.73m\^2 at screening
- Note: other protocol defined inclusion / exclusion criteria apply
Who the study is looking for
- Is an adult patient with a body mass index ≥30 kg/m\^2 to \<40 kg/m\^2
- Has a hemoglobin A1c \<6.5%
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| - Coordinator of this site? Confirm its status | Mount Royal | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.