NCT07624396Recruiting
Association Between Circulating BDNF Levels and Cardioembolic Strokes in Patients Treated for Ischemic Stroke
Source: ClinicalTrials.gov · Last updated 25 Sept 2026
Brief summary (registry, in English)
Atrial fibrillation (AF) is associated with serious complications, including embolic strokes, heart failure, and mortality. Disruption of normal blood flow in the atrium, particularly in the context of an endocardium predisposed to thrombosis, increases the risk of thrombus formation. Once dislodged from the atrial cavity and traveling to the cerebral arteries, these thrombi can cause a cardioembolic stroke. The main risk factors for atrial cardiomyopathy (ACM) and AF are metabolic syndrome and aging. ACM is a condition that is difficult to diagnose because it is not clearly defined, except through histological analysis. Guided by the results of our experimental approaches, the investigators aim to address this challenge by examining ACM through the lens of one of its complications: cardioembolic stroke. BDNF (Brain-Derived Neurotrophic Factor) is a neurotrophic factor involved in inflammatory and metabolic processes that may play a key role in the development of these complications. This study explores the association between circulating levels of BDNF and the morphological and metabolic characteristics of ACM, as assessed by cardiac and brain imaging studies
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 150 (estimated)
- First submitted
- 17 Apr 2026
- Start date
- 23 Sept 2026
- Primary completion date
- Sept 2031
- Lead sponsor
- Centre Hospitalier Universitaire Dijon
- Diseases
- Stroke
- NCT number
- NCT07624396
What you commit to
- Study type: Observational
- Planned participants: 150
- From 23 Sept 2026 to the primary completion date, Sept 2031
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- A person subject to a legal protective measure (guardianship, conservatorship)
- A person subject to a judicial safeguard measure
- A pregnant woman, a woman who has recently given birth, or a breastfeeding woman
- An adult who is legally incapacitated or unable to give consent,
- A minor
Who the study is looking for
- Individuals who provided informed consent
- Diagnosis of acute ischemic stroke confirmed by brain imaging (CT or MRI)
- Patient admitted to the USINV of the Department of General, Vascular, and Degenerative Neurology at the Dijon Bourgogne University Hospital during the inclusion period
- Underwent a combined cardiac and brain CT scan within 24 hours of admission for stroke
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Chu Dijon Bourgogne Coordinator of this site? Confirm its status | Dijon | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.