NCT07626242Not yet recruiting
Effect of Non-invasive Vagus Nerve Stimulation on Cerebrovascular Reactivity and Cognition in Chronic Stroke Patients
Source: ClinicalTrials.gov · Last updated 4 Jun 2026
Brief summary (registry, in English)
This study will be conducted to assess the effect of non-invasive vagus nerve stimulation on cerebrovascular reactivity and cognition in chronic stroke patients
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 31 May 2026
- Start date
- Jun 2026
- Primary completion date
- 15 Feb 2027
- Lead sponsor
- Cairo University
- Diseases
- Stroke
- NCT number
- NCT07626242
What you commit to
- Study type: Interventional
- Planned participants: 40
- From Jun 2026 to the primary completion date, 15 Feb 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with any taVNS contraindications (open heart surgery, pacemaker or other implants, previous surgical intervention on Vagus nerve, Facial or ear pain, and recent ear trauma)
Other illness
- Patients with other neurological disease that affect cognition.
- History of psychiatric disease.
- Hemorrhagic stroke patients.
- Uncontrolled blood pressure or low heart rate.
- Stroke patients with severe cognitive impairment.
Lab values
- Uncontrolled diabetes (\>130 mg/dL especially if consistently over 150 to 160 mg/dL)
Other
- The patients will be excluded if they have one of the followings:
- Visual, verbal or hearing impairments that can interfere with communication.
- Depression assessed by Hamilton Depression Scale (Ham-D).
- Patients with poor bone window.
- Uncooperative patients.
Who the study is looking for
- Forty chronic ischemic hemiparetic patients, of both sexes, will represent the sample.
- The patient's age will range from 50 to 60 years old.
- Duration of illness will range from six months to twelve months.
- Patients with mild cognitive impairment according to Montreal Cognitive Assessment (MoCA) scale (from 18 to 25).
- Spasticity will be 1 or 1+ according to Modified Aschworth scale.
- Educated patients.
Age in the registry: 50 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ahmed Safwat Kamal Coordinator of this site? Confirm its status | Cairo | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.