NCT07629804Completed
Measuring Blood Vessel Density in the Optic Nerve of Multiple Sclerosis Patients With OCTA
Quantitative OCT Angiography Differences in Optic Nerve Vascular Density in Multiple Sclerosis: A Case-Control Study
Source: ClinicalTrials.gov · Last updated 5 Jun 2026
Brief summary (registry, in English)
The goal of this observational study is to learn about the effect of multiple sclerosis on the blood flow of the optic nerve of affected patients compared to normal subjects by OCTA. The main question it aims to answer is: 1. Does MS change the blood flow in the optic nerve? 2. If it does, can measuring this blood flow be used as a simple sign (a biomarker) to help doctors understand and manage MS? We used a quick and painless eye scan called Optical Coherence Tomography Angiography (OCTA). This special scan takes detailed pictures of the blood vessels in the optic nerve without needing any injections. We performed this scan on two groups of people: one group with MS and one group without MS, and then compare the results. In simple terms, why is this important? If we can show that MS affects the optic nerve blood vessels, it could give us a new, quick way to monitor the disease and see how it is progressing, just by doing a simple eye scan.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 54 (actual)
- First submitted
- 26 Sept 2025
- Start date
- 5 Jan 2025
- Primary completion date
- 3 Aug 2025
- Lead sponsor
- Fayoum University
- Diseases
- Multiple sclerosis
- NCT number
- NCT07629804
What you commit to
- Study type: Observational
- Participants enrolled: 54
- From 5 Jan 2025 to the primary completion date, 3 Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Other optic nerve diseases as glaucoma, papilledema or conginetal anomalies.
- Other macular diseases as AMD, CSR, scars …
Other
- Errors of refraction outside +4 and -6 D range.
- Media opacity as cataracts or corneal opacities that may interfere with the quality of scans.
- Signal strength index less than 4\\10.
Who the study is looking for
- group 1; patients with multiple sclerosis with optic neuritis.
- group 2; normal healthy age matched controls
Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fayoum University Hospital Coordinator of this site? Confirm its status | Al Fayyum | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.