NCT07630857Recruiting
Unipolar Voltage Mapping for Personalized Atrial Fibrillation Ablation
Unipolar Mapping for Personalized Atrial Fibrillation Ablation: An Interventional Study on Arrhythmia Maintenance and Atrial Remodeling
Source: ClinicalTrials.gov · Last updated 16 Jun 2026
Brief summary (registry, in English)
Atrial fibrillation (AF) is a common heart rhythm disorder. While catheter ablation is an effective treatment, many patients still experience AF recurrence after the procedure. One major reason is that the mechanisms that maintain AF are not fully understood. Research suggests that the outer layer of the heart (epicardium) may play an important role in keeping AF going. However, current mapping techniques have limitations in detecting electrical signals from both the inner and outer heart layers. This study uses a different technique called unipolar voltage mapping, which may more accurately capture electrical signals from both heart layers. Specifically, we focus on a specific type of electrical signal called "QS potential" on unipolar mapping, which reflects breakthrough sites between the inner and outer heart layers. In this interventional study, participants with AF undergoing catheter ablation will receive personalized ablation guided by unipolar QS-potential mapping. We aim to: Explore the relationship between unipolar QS-potentials and AF maintenance and atrial remodeling Evaluate the effectiveness of QS-potential guided personalized AF ablation
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- First submitted
- 2 Jun 2026
- Start date
- 20 Jun 2026
- Primary completion date
- 19 Sept 2026
- Lead sponsor
- China National Center for Cardiovascular Diseases
- Diseases
- Atrial fibrillation
- NCT number
- NCT07630857
What you commit to
- Study type: Interventional
- Planned participants: 200
- From 20 Jun 2026 to the primary completion date, 19 Sept 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participation in another interventional clinical trial within 30 days prior to enrollment
Other illness
- Severe valvular heart disease (moderate to severe mitral stenosis or regurgitation)
- History of intracardiac thrombus
- Active infection or sepsis
- Life expectancy \< 12 months due to comorbid conditions
Lab values
- Left ventricular ejection fraction \< 35%
Other
- Contraindication to anticoagulation
- Pregnancy or breastfeeding
Who the study is looking for
- Age ≥ 18 years and ≤ 80 years
- Documented diagnosis of atrial fibrillation (paroxysmal or persistent)
- Planned to undergo catheter ablation for AF (including patients with recurrent AF after prior ablation)
- Able and willing to provide written informed consent
- Able to complete scheduled follow-up visits (3 months post-ablation)
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fuwai Hospital Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.