NCT07631299Not yet recruitingEarly phase 1
Nebulized AER101 in Pre-op NSCLC
Nebulized AER101 to Inhibit Glycolysis for Pre-Operative Non-small Cell Lung Cancer (NSCLC)
Source: ClinicalTrials.gov · Last updated 8 Jun 2026
Brief summary (registry, in English)
The primary objective of this pilot study is to determine if AER101 can decrease glycolysis in non-small cell lung cancer (NSCLC). Glycolysis is the process cells use to break down sugar (glucose) into a smaller substance in the fluid part inside the cell. Many lung cancers begin in bronchi, bronchioles and alveoli cells surrounding the airways, which enables nebulization to deposit AER101 on lung tumors. Participants in the study will self-administer AER101 via a hand-held personal nebulizer three times per day (dosing at least 4 hours apart) for 14 days prior to undergoing surgery for lung cancer.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 5 (estimated)
- First submitted
- 27 May 2026
- Start date
- Jun 2026
- Primary completion date
- Dec 2026
- Lead sponsor
- University of Oklahoma
- Diseases
- Lung cancer
- NCT number
- NCT07631299
What you commit to
- Study type: Interventional · Early phase 1
- Planned participants: 5
- From Jun 2026 to the primary completion date, Dec 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Recurrent tumor(s)
- Nodal or metastatic tumor (multiple lung tumors are acceptable)
- Pregnant patients
- Patients unable to provide informed consent
- Prisoners
Who the study is looking for
- 18 years or older
- Agree to sign consent and follow study requirements
- Recently diagnosed with lung adenocarcinoma or squamous cell carcinoma
- Primary patients prior to resection
- Candidate for surgery (patients are qualified for inclusion if surgery or radiation treatment are agreed to)
- Baseline PET/CT imaging performed at Stephenson Cancer Center available and performed within previous 30 days
Age in the registry: 18 years to 100 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Stephenson Cancer Center Coordinator of this site? Confirm its status | Oklahoma City | United States | Unknown status |
| OU Medical Center Hospital Coordinator of this site? Confirm its status | Oklahoma City | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.