NCT07631598Recruiting
Buprenorphine Implementation at Syringe Service Programs to Reduce Overdoses
Buprenorphine Implementation at Syringe Services Programs To Reduce Overdoses: A Type 1 Hybrid Effectiveness-Implementation Trial
Source: ClinicalTrials.gov · Last updated 1 Oct 2026
Brief summary (registry, in English)
This study is testing whether offering buprenorphine treatment directly at syringe service programs (SSPs) helps more people start and stay in treatment for opioid use disorder (OUD) than referring them to community buprenorphine treatment providers. Buprenorphine is a medication that helps reduce opioid cravings and withdrawal symptoms. The study compares two ways of connecting people to treatment: Referral to a community treatment provider (usual care before the new program begins). Onsite, low-threshold buprenorphine treatment at the SSP, which allows participants to start medication quickly and without having to establish care at another provider. Participants will be adults who have opioid use disorder and are SSP clients. Each SSP will begin offering the new onsite buprenorphine program at different times during the study. Researchers will collect information before and after the new program begins to see how it affects treatment engagement and health outcomes. The study will also examine how easy or difficult it is for SSPs to start and run the new program, how acceptable it is to staff and participants, and whether it is cost-effective. The overall goal is to find better ways to expand access to life-saving opioid treatment in community-based settings.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 512 (estimated)
- First submitted
- 1 Jun 2026
- Start date
- 17 Aug 2026
- Primary completion date
- Feb 2028
- Lead sponsor
- Montefiore Medical Center
- NCT number
- NCT07631598
What you commit to
- Study type: Interventional
- Planned participants: 512
- From 17 Aug 2026 to the primary completion date, Feb 2028
- 8 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Unstable mental health or medical condition that requires an immediate clinical evaluation or higher level of care;
- Allergy to buprenorphine;
Other
- Current use of prescribed opioid agonist treatment, as assessed by self-report, at the time of enrollment;
- Currently detained in jail, prison, residential substance use treatment facility, or other overnight facility as required by court of law. or have pending legal action that could prevent participation on study activities.
Who the study is looking for
- ≥ 18 years old;
- Meet DSM-5 criteria for moderate or severe OUD;
- Interest in receiving buprenorphine treatment;
- Speaks English or Spanish;
- Currently an SSP client at the time of enrollment;
- Ability to provide informed consent.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (8)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CARPBR/Be Safe Syringe Program Coordinator of this site? Confirm its status | Baton Rouge | United States | Recruiting |
| Harm Reduction Sisters Coordinator of this site? Confirm its status | Duluth | United States | Recruiting |
| HIV Alliance Coordinator of this site? Confirm its status | Grants Pass | United States | Recruiting |
| Challenges, Inc/Prisma Health Coordinator of this site? Confirm its status | Greenville | United States | Recruiting |
| Community Health Project Los Angeles (CHPLA) Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
| Vivent Health Coordinator of this site? Confirm its status | Milwaukee | United States | Recruiting |
| Alianza of New Mexico Coordinator of this site? Confirm its status | Roswell | United States | Recruiting |
| HIPS Coordinator of this site? Confirm its status | Washington D.C. | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.