NCT07632755Recruiting
Validation of a Remediation Method for Memory Impairments Through Motor Encoding in Patients With Alzheimer's Disease
Source: ClinicalTrials.gov · Last updated 31 Jul 2026
Brief summary (registry, in English)
In France, over 1.5 million people suffer from mild cognitive impairment, often a precursor to Alzheimer's disease (AD), whose global prevalence could reach 153 million by 2050. With no curative treatment available, maintaining patients' autonomy at home is essential to mitigate the negative effects of institutionalization and reduce economic costs. Non-pharmacological approaches, such as cognitive training, have shown potential in stabilizing cognitive functions. Research suggests that motor networks and procedural memory remain relatively preserved in early AD, and bodily engagement during encoding enhances memory. For patients with motor impairments, motor imagery (MI) activates these networks without actual movement. Additionally, dynamic visual cues, like videos, reduce cognitive load compared to static images. This project aims to combine real action, MI, and dynamic visual supports to optimize memory. By validating 120 videos of daily activities, it will assess the impact of action on recall, evaluate MI's effectiveness for patients with mobility limitations, and confirm the superiority of videos over static images. The results could support the development of digital tools, such as serious games, to enhance patients' autonomy and address aging-related challenges.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- First submitted
- 2 Jun 2026
- Start date
- 15 Jul 2026
- Primary completion date
- Mar 2028
- Lead sponsor
- Centre Hospitalier Universitaire de Saint Etienne
- Diseases
- Alzheimer disease
- NCT number
- NCT07632755
What you commit to
- Study type: Interventional
- Planned participants: 80
- From 15 Jul 2026 to the primary completion date, Mar 2028
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Medical treatment affecting vision, language, or motor skills (or participation in a study involving a drug or device that influences cognition).
Other
- Uncorrected visual or hearing impairments
- Language or motor impairments
- Delirium or psychosis.
- Refusal to participate.
- Inability to communicate
- Persons deprived of liberty by a judicial or administrative decision and adults subject to a legal protection measure or unable to express their consent
Who the study is looking for
- Patient group: Diagnosis of Alzheimer's disease made by one of the consulting physicians-a neurologist and/or geriatrician (Dubois et al., 2014)-at the early stage, presenting with mild memory impairment of which the patient has been informed
- \- MMSE score of 21 or higher
- Control group: individuals without a diagnosis of Alzheimer's disease, but meeting the other criteria listed below
- Enrollment in a social security program
- Age 60 or older
- French as a native language
- Consent to participate
Age in the registry: 60 years to - · Sex: All · Accepts healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Chu Grenoble Coordinator of this site? Confirm its status | Grenoble | France | Not yet recruiting |
| Chu de Saint Etienne Coordinator of this site? Confirm its status | Saint-Etienne | France | Recruiting |
| HLC, Hôpital des Charpennes Coordinator of this site? Confirm its status | Villeurbanne | France | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.