NCT07635797Not yet recruiting
Effectiveness of Subgingival Instrumentation on Delaying End-stage Renal Disease Among Chronic Kidney Disease Patients
Effectiveness of Subgingival Instrumentation on Delaying End-stage Renal Disease Among Chronic Kidney Disease Patients: A Non-Randomized Clinical Study
Source: ClinicalTrials.gov · Last updated 18 Jun 2026
Brief summary (registry, in English)
Chronic kidney disease (CKD) and periodontitis share a bidirectional inflammatory relationship, with cytokines such as IL-6, TNF-α, and hsCRP driving progression in both conditions. Non-surgical periodontal therapy (NSPT) has shown reductions in systemic inflammatory markers with emerging evidence of improved renal function, yet robust randomized controlled trials targeting pre-dialysis stage IV-V diabetic CKD patients remain lacking. In the Indian context, where diabetes-related CKD is rapidly rising and access to dialysis is limited, there is a clear lacuna in literature regarding the effectiveness of NSPT in delaying progression to end-stage renal disease. Hence, the present non-randomized clinical study is undertaken to address this gap.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 3 Jun 2026
- Start date
- 1 Jul 2026
- Primary completion date
- 31 Jul 2027
- Lead sponsor
- Postgraduate Institute of Dental Sciences Rohtak
- Diseases
- Chronic kidney disease
- NCT number
- NCT07635797
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 1 Jul 2026 to the primary completion date, 31 Jul 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients already undergoing haemodialysis or renal transplantation.
- Patients on insulin therapy or taking SGLT2 inhibitors and GLP-1 receptor agonists.
- Any Periodontal therapy within past 6 months.
Other illness
- Any history of tobacco use.
Lab values
- HbA1c level \>8 %.
Other
- Immunocompromised patients.
- Pregnant or lactating women.
Who the study is looking for
- Patients aged 40-70 years.
- Type 2 diabetes mellitus with chronic kidney disease and currently on oral hypoglycaemic agents.
- Diagnosed with Stage IV or V (eGFR between 15-20 mL/min/1.73m²).
- Not undergoing dialysis.
- Presence of ≥20 natural teeth.
- Diagnosed with moderate (Stage II) (as per 2017 World Workshop classification) (Interdental CAL at site of greatest loss \>2mm but \<5 mm in ≥ 2 non-adjacent teeth).
- Willingness to provide written informed consent.
Age in the registry: 40 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Post Graduate institute of Dental Sciences, Rohtak Coordinator of this site? Confirm its status | Rohtak | India | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.