NCT07636343Recruiting
Eccentric Muscle Training in Cardiac Rehabilitation
Eccentric Muscle Training in Cardiac Rehabilitation: Randomized Controlled Trial to Evaluate Effectiveness and Feasibility in Heart Failure Patients With Reduced Ejection Fraction
Source: ClinicalTrials.gov · Last updated 9 Jun 2026
Brief summary (registry, in English)
The goal of this interventional study is to assess the training effects in a training schedule in which eccentric overload training and eccentric cycle training are used. Researchers will compare a training program of eccentric overload training and eccentric cycling training with a traditional training program of strength and cardio training in people with heart failure with reduced ejection fraction. This study will be delivered in a cardiac rehabilitation setting.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 3 (estimated)
- First submitted
- 1 Dec 2025
- Start date
- 20 Jan 2023
- Primary completion date
- 30 Sept 2026
- Lead sponsor
- University Hospital, Antwerp
- Diseases
- Heart failure
- NCT number
- NCT07636343
What you commit to
- Study type: Interventional
- Planned participants: 3
- From 20 Jan 2023 to the primary completion date, 30 Sept 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Contra indications for cardiac exercise rehabilitation as per consensus guidelines and recommendations
- Musculoskeletal disorders that hamper (progression in) strength training
- Non-stabilized acute coronary syndrome
- Current acute heart failure (decompensation)
- Patient having sustained a recent (\<3 months) procedure that could act as a confounder to increase VO2peak (i.e., coronary artery bypass graft surgery, percutaneous coronary intervention, cardiac resynchronization therapy, valve surgery or reparation)
Who the study is looking for
- HFrEF patients with ejection fraction \<40%
- Exercise intolerance (\<85% of predicted VO2 peak)
- clinically stable for \> 6 weeks, optimal medical treatment for \> 6 weeks
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UHAntwerp Coordinator of this site? Confirm its status | Edegem | Belgium | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.