NCT07638176Recruiting
Effect of Individualized Positive End-expiratory Pressure (PEEP) in Patients Who Have an Intrinsic PEEP During One-lung Ventilation
Effects of Individualized Positive End-expiratory Pressure (PEEP) on Intrinsic PEEP and Stroke Volume During One-lung Ventilation: a Single-center, Randomized Crossover Study
Source: ClinicalTrials.gov · Last updated 14 Sept 2026
Brief summary (registry, in English)
This study investigates the effects of three extrinsic PEEP settings-5 cmH2O, 0 cmH2O, and an individualized PEEP (70% of the measured intrinsic PEEP)-on intrinsic PEEP and hemodynamic stability in patients with intrinsic PEEP undergoing lung resection surgery, using a randomized, crossover design.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 48 (estimated)
- First submitted
- 21 May 2026
- Start date
- 1 Aug 2026
- Primary completion date
- 31 May 2027
- Lead sponsor
- Samsung Medical Center
- Diseases
- Stroke
- NCT number
- NCT07638176
What you commit to
- Study type: Interventional
- Planned participants: 48
- From 1 Aug 2026 to the primary completion date, 31 May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Emergency surgery
- Mechanical ventilation before surgery
- Hemodynamic instability before surgery
- Surgery requiring cardiopulmonary bypass
Other
- Large bullae
- Pregnancy, breastfeeding patient
- Patient's refusal to participate
- No intrinsic PEEP during one-lung ventilation
Who the study is looking for
- American Society of Anesthesiologists Physical Status I - III
- The Eastern Cooperative Oncology Group Performance Status Grade 0 - 2
- Lung resection surgery requiring one-lung ventilation for over 60 minutes
- Indication of double-lumen endobronchial tube (female 35 Fr, male 37 Fr)
- Patient who is diagnosed with intrinsic PEEP during one-lung ventilation
Age in the registry: 19 years to 100 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Samsung Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.