NCT07638592Completed
Tirzepatide-Based Prehabilitation Before Elective Ventral and Incisional Hernia Repair in Patients With Obesity
Tirzepatide-Based Prehabilitation Before Elective Ventral and Incisional Hernia Repair in Patients With Obesity:A Prospective Multicenter Cohort Study With a Comparative Control Cohort
Source: ClinicalTrials.gov · Last updated 11 Jun 2026
Brief summary (registry, in English)
This study evaluated whether a 16-week weight-loss program using tirzepatide before elective ventral and incisional hernia surgery could improve surgical readiness and outcomes in patients with obesity. In this retrospective multicenter study, 109 patients entered the program, and 91 completed treatment and underwent surgery. Participants achieved an average weight loss of 13.8%, and all patients who completed the program reached the target weight required for surgery. Compared with a control group of obese patients who underwent hernia repair without pharmacological prehabilitation, the tirzepatide group experienced fewer postoperative wound-related complications.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 91 (actual)
- First submitted
- 5 Jun 2026
- Start date
- 1 Jan 2025
- Primary completion date
- 1 Jun 2026
- Lead sponsor
- Azienda Sanitaria Locale Napoli 2 Nord
- Diseases
- Obesity
- NCT number
- NCT07638592
What you commit to
- Study type: Observational
- Participants enrolled: 91
- From 1 Jan 2025 to the primary completion date, 1 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Contraindication to tirzepatide (personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2; prior pancreatitis; severe gastrointestinal disease; pregnancy or lactation) Ongoing treatment with another anti-obesity medication
- Prior bariatric surgery within the preceding 12 months
Other
- Emergency presentation or incarcerated/strangulated hernia
- Hernia requiring posterior component separation or transversus abdominis release (TAR)
- Inability to comply with follow-up
Who the study is looking for
- Age ≥ 18 years
- Body mass index (BMI) ≥ 30 kg/m²
- Elective primary ventral or incisional midline hernia
- European Hernia Society (EHS) width W2 (4-10 cm) or W3 (\> 10 cm)
- Hernia amenable to a standard Rives-Stoppa retromuscular repair
- Able and willing to comply with the prehabilitation program and scheduled follow-up
Age in the registry: 18 years to - · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Francesco Pizza Coordinator of this site? Confirm its status | Naples | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.