NCT07638982Not yet recruitingPhase 1
Axatilimab + CAR-T for High-Risk Lymphoma
An Open-label, Phase I Trial, With an Expansion Cohort: Macrophage Conditioning to Synergize With CAR-T in High-risk Lymphoma (MAC-SHIFT)
Source: ClinicalTrials.gov · Last updated 16 Oct 2026
Brief summary (registry, in English)
Axatilimab + CAR-T in High-Risk Lymphoma
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 29 (estimated)
- First submitted
- 5 Jun 2026
- Start date
- 31 Dec 2026
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- Northside Hospital, Inc.
- NCT number
- NCT07638982
What you commit to
- Study type: Interventional · Phase 1
- Planned participants: 29
- From 31 Dec 2026 to the primary completion date, 31 Dec 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Allogeneic transplant within 100 days of enrollment
Other illness
- Second malignancy with a high metastatic potential within 3 years
- Active CNS involvement. Treated CNS disease is allowed
- Active HBV or HCV infection.
- Active uncontrolled infections
- Known HIV positive status
- Active acute or chronic graft versus host disease
- History of acute or chronic pancreatitis
- History of myositis
Other
- KPS \<60
Who the study is looking for
- Age ≥ 18 years
- Histologically confirmed large B-cell lymphoma
- Presence of one or more high-risk features
- Eligible to receive CAR-T according to the FDA label
- Measurable disease by CT or PET
- Adequate organ function unless related to lymphoma involvement:
- Pulse oximetry ≥ 92% on room air
- Ejection Fraction ≥ 40%
- ALT/AST \< 5x ULN
- Bilirubin \< 3 x ULN
- Calculated or measured creatinine Clearance ≥ 30 mL/min
Age in the registry: 8 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Northside Hospital Coordinator of this site? Confirm its status | Atlanta | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.