Adjuvant Therapy for High-Risk Intrahepatic Cholangiocarcinoma: A Real-World Study

Prior treatment

• Immunosuppressive therapy within 28 days prior to enrollment (excluding topical/inhaled corticosteroids or physiologic steroid doses ≤10 mg/day prednisone equivalent).
• Prior/proposed organ transplantation (excluding corneal grafts).
• Concurrent interventional trials or investigational drugs within 4 weeks without recovery to Grade ≤1 toxicity.
• Allogeneic transplant history/plans.

Other illness

• Active infections (IV antibiotics/antivirals required) or fever \>38.5°C within 4 weeks; or major surgery within 3 weeks.
• Hypersensitivity to study drug components.
• Uncontrolled psychiatric/substance abuse disorders.
• Refractory hypertension (≥140/90 mmHg despite treatment).
• Clinically significant bleeding/thromboembolism:
  • GI bleeding within 3 months Thrombotic events within 6 months (stroke, DVT/PE)
• Other high-risk conditions per investigator judgment.

Lab values

• Uncontrolled cardiovascular disease:
  • Unstable angina/myocardial infarction Arrhythmias with QTc ≥450 ms (men) or ≥470 ms (women) NYHA Class III-IV heart failure or LVEF \<50%
• Active autoimmune/immunodeficiency diseases (e.g., hepatitis, pneumonitis, rheumatoid arthritis), except:
  • Hypothyroidism on stable hormone replacement Type 1 diabetes with controlled glucose Uncontrolled asthma requiring systemic bronchodilators (resolved childhood asthma allowed).
  • \- Active infections: HIV/AIDS
  • HBV (DNA ≥500 IU/mL) or HCV (RNA-positive) unless:
  • HBV DNA \<500 IU/mL + antiviral therapy ≥14 days
• Coagulopathy (INR \>1.5, PT \>ULN+4s, aPTT \>1.5×ULN) or anticoagulant use.

Other

• Systemic anticancer herbs/immunomodulators (e.g., thymosin, interferons) within 4 weeks, except for pleural effusion control.
• Proteinuria ≥++ on dipstick or 24-h urine protein ≥1 g.

• Histologically confirmed ICC within 12 weeks after curative resection
• Any T stage; N0/N+; M0.
• At least one high-risk factor:
  • Preoperative tumor penetration of the liver capsule or extrahepatic direct invasion; Preoperative imaging showing multifocal lesions or a single lesion \>5 cm; Vascular invasion (preoperative or postoperative pathology); Regional lymph node metastasis.
• No prior systemic therapy for ICC.
• ECOG performance status 0-2.
• Expected survival ≥3 months.
• Adequate organ function.
• Agreement to use effective contraception (or surgical sterilization) during the study and for 120 days after the last dose.
• Signed informed consent and anticipated good compliance with the study protocol.