NCT07640399Completed
Stannous Fluoride Toothpaste for Reduction and Treatment of Gingivitis
Efficacy of a Stannous Fluoride Toothpaste in the Reduction and Treatment of Gingivitis: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 10 Jun 2026
Brief summary (registry, in English)
This study evaluated the efficacy of a stannous fluoride toothpaste compared to a sodium fluoride control toothpaste in reducing gingivitis, bleeding, and plaque over a 12-week period. A total of 132 subjects were randomized to one of two treatment groups and assessed at baseline and at Weeks 2, 4, 8, and 12 using standardized clinical indices, including the Modified Gingival Index (MGI), Bleeding Index (BI), and Plaque Index (PI).
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 133 (actual)
- First submitted
- 2 Jun 2026
- Start date
- Mar 2025
- Primary completion date
- Jun 2025
- Lead sponsor
- Church & Dwight Company, Inc.
- NCT number
- NCT07640399
What you commit to
- Study type: Interventional
- Participants enrolled: 133
- From Mar 2025 to the primary completion date, Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Requirement for premedication prior to dental treatment
- Dental prophylaxis within 1 month prior to baseline visit
Other illness
- Poor oral hygiene defined as \>40 bleeding sites
- History of significant adverse events, allergy, or irritation related to oral hygiene products
Other
- Physical limitations or restrictions that preclude normal tooth brushing
- Pregnancy or intent to become pregnant during the study period
- Use of tobacco or nicotine products
- Presence of dental caries or calculus deposits that may interfere with plaque assessments
- Major oral hard or soft tissue lesions or trauma at baseline
- Presence of fixed or removable orthodontic appliances
Who the study is looking for
- Male or female subjects aged 18 to 65 years (inclusive)
- Provided written informed consent prior to participation
- Able to brush their own teeth on a daily basis
- In good general health based on medical history review
- Minimum of at least 18 natural, scorable teeth
- Mean plaque index score ≥ 1.95
- Mean baseline gingival index score ≥ 1.70 and ≤ 3.0
- Agreed to refrain from use of all oral hygiene products other than those supplied for the study
- Agreed to refrain from oral hygiene, eating, drinking, and chewing gum for approximately 12 hours prior to study visits
- Agreed not to undergo dental prophylaxis or elective dental procedures during the study
- Willing and able to comply with study procedures and visit schedule
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| All Sum Coordinator of this site? Confirm its status | Mississauga | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.