NCT07640659Not yet recruiting
Using Breath Tests to Study Gut Sulfur Changes During Dietary Therapy
Sulfur on the Breath: Using Breath Biomarkers to Monitor Gut Microbial Sulfur Metabolism During Elemental and Reduced Sulfur Dietary Therapy
Source: ClinicalTrials.gov · Last updated 11 Jun 2026
Brief summary (registry, in English)
This study aims to test whether a short liquid-based diet, followed by a low-sulfur eating plan, is safe, manageable, and helpful for people with mild to moderate ulcerative colitis. Investigators want to see if this approach can improve gut health, lower inflammation, and reduce symptoms. Investigators will also test breath samples as an easy, non-invasive way to track gut bacteria activity and disease changes. Investigators believe this diet plan can reduce harmful gut bacteria that produce irritating sulfur compounds, leading to better gut health and measurable improvements that can be detected through breath testing.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 45 (estimated)
- First submitted
- 29 May 2026
- Start date
- 1 Jun 2026
- Primary completion date
- 1 Mar 2029
- Lead sponsor
- University of British Columbia
- Diseases
- Ulcerative colitis
- NCT number
- NCT07640659
What you commit to
- Study type: Interventional
- Planned participants: 45
- From 1 Jun 2026 to the primary completion date, 1 Mar 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Antibiotic use within 3 months prior to enrollment.
- Probiotic use within 3 months prior to enrollment.
Other illness
- History of an eating disorder.
- Severe psychiatric disorder.
- Severe medical conditions, including:
- Active cancer;
- Significant cardiovascular disease;
- Diabetes mellitus; or
- Severe food allergies.
- Known allergy or intolerance to corn, dextrose, or maltodextrin.
- History of major gastrointestinal surgery, including:
- Short bowel syndrome.
Other
- Partial Mayo score (pMayo) \> 7.
- Pregnant or breastfeeding.
- Body mass index (BMI) \< 18 kg/m².
- Use of herbal anti-inflammatory supplements during the study period, including but not limited to:
- Serrapeptidase;
- Curcumin;
- Boswellia; or
- Bromelain.
- Ostomy;
- Total colectomy; or
- Inability or unwillingness to comply with study procedures, including anticipated travel or other commitments that may interfere with participation.
Who the study is looking for
- Age 19-70 years.
- =Diagnosis of mild-to-moderate ulcerative colitis, defined by a partial Mayo score (pMayo) of 2-7.
- Evidence of active inflammation at enrollment, defined as:
- C-reactive protein (CRP) \> 5 mg/L; or
- Fecal calprotectin (FCP) \> 200 µg/g.
- Receiving stable medical therapy for ulcerative colitis for at least 8 weeks prior to enrollment.
- No corticosteroid use at the time of recruitment.
- Under consideration by the treating physician for treatment escalation or biologic switch due to inadequate response to current therapy.
Age in the registry: 19 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of British Columbia Okanagan Coordinator of this site? Confirm its status | Kelowna | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.