NCT07643974Not yet recruitingEarly phase 1
Coupled Gentamicin-Lactobacillus Rhamnosus in NLUTD
Effect of Dose Timing of Coupled Intravesical Gentamicin and Lactobacillus Rhamnosus LGG on Success and Length of Colonization in Men and Women With SCI/D and NLUTD
Source: ClinicalTrials.gov · Last updated 21 Aug 2026
Brief summary (registry, in English)
The main objective of the proposed research study is to determine in men and women with spinal cord injury/disease and neurogenic bladder whether the dose of coupled gentamicin \& Lactobacillus rhamnosus GG affects the recolonization of the bladder, and whether the rate of success differs by sex. Secondary objectives include determining whether that recolonization lasts 7, 14, or 28 days; and safety of the coupled gentamicin \& Lactobacillus instillations.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 48 (estimated)
- First submitted
- 8 Jun 2026
- Start date
- Aug 2026
- Primary completion date
- Sept 2027
- Lead sponsor
- Medstar Health Research Institute
- Diseases
- Multiple sclerosis
- NCT number
- NCT07643974
What you commit to
- Study type: Interventional · Early phase 1
- Planned participants: 48
- From Aug 2026 to the primary completion date, Sept 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Psychologic or psychiatric conditions influencing the ability to follow instructions
- Allergy to ampicillin, daptomycin, gentamicin/gentamycin, or probiotics
Other
- Known genitourinary pathology beyond NLUTD (i.e. kidney stones, bladder stones, vesicoureteral reflux, etc.)
- Use of prophylactic antibiotics or any antibiotics within 2 weeks of beginning instillations
- Instillation of intravesical agents other than saline bladder wash
- Immunodeficiency
- Participation in another study which could confound results
Who the study is looking for
- Neurologic diagnosis
- ≥18 years old
- Neurogenic bladder for at least 6 months
- No USQNB-IC A, B1, or B2 symptoms
- No currently diagnosed UTI (within 24 hours of initiating instillations)
- Community dwelling (not in acute hospital setting)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Pittsburgh Medical Center Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
| MedStar National Rehabilitation Hospital Coordinator of this site? Confirm its status | Washington D.C. | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.