NCT07645066Recruiting
Posterosuperior Bundle Pacing for Prevention of Atrial Fibrillation in Patients With Sinus Node Dysfunction
A Prospective, Multicenter, Randomized Controlled Trial Evaluating the Effect of Posterosuperior Bundle Pacing on Atrial Fibrillation Prevention in Patients With Sinus Node Dysfunction
Source: ClinicalTrials.gov · Last updated 23 Sept 2026
Brief summary (registry, in English)
This study aims to evaluate whether posterosuperior bundle (PSB) pacing reduces the incidence of atrial fibrillation (AF) in patients with sinus node dysfunction (SND) undergoing pacemaker implantation. Approximately 300 patients will be enrolled and randomized to receive atrial pacing at either the PSB region or the right atrial appendage (RAA). The primary endpoint is the occurrence of AF episodes lasting ≥6 minutes, as detected by device or surface electrocardiogram. Patients will be followed for up to 24 months.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 300 (estimated)
- First submitted
- 18 May 2026
- Start date
- 25 Aug 2026
- Primary completion date
- 1 Feb 2029
- Lead sponsor
- Shanghai Tong Ren Hospital
- Diseases
- Atrial fibrillation
- NCT number
- NCT07645066
What you commit to
- Study type: Interventional
- Planned participants: 300
- From 25 Aug 2026 to the primary completion date, 1 Feb 2029
- 10 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Persistent atrial fibrillation (AF) (\>7 days), long-standing persistent AF, permanent AF, or prior atrioventricular node ablation
- Prior cardiac implantable electronic device (CIED) requiring replacement, upgrade, or revision
- Prior cardiac surgery, severe hepatic or renal dysfunction, or other life-threatening systemic diseases
- Acute myocardial infarction within 3 months before enrollment
Other illness
- Indication for cardioverter-defibrillator (ICD) or cardiac resynchronization therapy (CRT-D)
- Any condition that, in the opinion of the investigator, makes participation unsuitable
Other
- Persistent left superior vena cava or dextrocardia
- Pregnant or breastfeeding women, or women of childbearing potential not using effective contraception
- Participation in another clinical trial that may interfere
Who the study is looking for
- Age ≥18 years
- Indication for permanent pacemaker implantation, including:
- Sinus node dysfunction, defined as at least one of the following:
- Symptomatic sinus bradycardia
- Tachy-brady syndrome
- Chronotropic incompetence
- Sinus pause / arrest
- Atrioventricular block (if present); if ventricular pacing is required, left bundle branch area pacing is planned
- Expected survival \>1 year
- Panned implantation of a device capable of detecting atrial high-rate episodes
- Willing and able to provide informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (10)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| China Medical University affiliated AnQing Municipal Hospital Coordinator of this site? Confirm its status | Anqing | China | Not yet recruiting |
| Shanghai Jiaotong University affiliated Shanghai Ninth People's Hospital Coordinator of this site? Confirm its status | Shanghai | China | Not yet recruiting |
| Shanghai University of Traditional Chinese Medicine affiliated Putuo Hospital Coordinator of this site? Confirm its status | Shanghai | China | Not yet recruiting |
| Tong Ren Hospital, Shanghai Jiaotong University School of Medicine Coordinator of this site? Confirm its status | Shanghai | China | Recruiting |
| Fudan University Affiliated Huadong Hospital Coordinator of this site? Confirm its status | Shanghai | China | Not yet recruiting |
| Tongji University School of Medicine affiliated Tongji University Coordinator of this site? Confirm its status | Shanghai | China | Not yet recruiting |
| Shanghai Jiaotong University affiliated Shanghai Sixth People's Hospital Coordinator of this site? Confirm its status | Shanghai | China | Not yet recruiting |
| Tongling People's Hospital Coordinator of this site? Confirm its status | Tongling | China | Not yet recruiting |
| Wuhan Asia General Hospital Coordinator of this site? Confirm its status | Wuhan | China | Not yet recruiting |
| Affiliated Hospital of Zunyi Medical College Coordinator of this site? Confirm its status | Zunyi | China | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.