NCT07645391Recruiting
Targeted Early Detection Program in Men at High Genetic Risk for Prostate Cancer
Source: ClinicalTrials.gov · Last updated 12 Jun 2026
Brief summary (registry, in English)
This study evaluates urinary biomarkers and PSA to help determine the best approach to early detection of prostate cancer in patients with an elevated familial risk.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 8 Jun 2026
- Start date
- 1 Jan 2017
- Primary completion date
- Jan 2030
- Lead sponsor
- University of Michigan Rogel Cancer Center
- Diseases
- Prostate cancer
- NCT number
- NCT07645391
What you commit to
- Study type: Observational
- Planned participants: 200
- From 1 Jan 2017 to the primary completion date, Jan 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- \* Anuria
- Prior diagnosis or treatment for PCa
- Failure to provide informed consent
- Life expectancy \< 5 years
Who the study is looking for
- \* Age 35-70 years
- Capable of providing informed consent
- Prognosis of \> 5 years if affected by another cancer
- Patients need one to meet at least one of the following high genetic risk categories:
- Known PCa-related mutations: BRCA 1 and 2, Lynch syndrome, or p53
- Carrier of mutation in a suspected PCa-related gene: e.g., ATM, PALB2, CHEK2, RAD51D, ATR, NBN, GEN1, RAD51C, MRE11A, BRIP1, FAM175A, HOXB13
- Obligate carriers of the above mutations (e.g. their sisters/daughters have known mutations)
- Men with any family history of above mutation
- Family history of breast, prostate, or ovarian cancer in at least 2 individuals, or in 1 individual diagnosed before age 50
Age in the registry: 35 years to 70 years · Sex: Male · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Michigan Rogel Cancer Center Coordinator of this site? Confirm its status | Ann Arbor | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.