NCT07645794Enrolling by invitation
Clinical Study on a New Diagnostic Strategy for Osteoporosis and Sarcopenia in Chronic Kidney Disease Patients Based on MRI-FF
A Clinical Study on Establishing a New Diagnostic Strategy for Osteoporosis and Sarcopenia in Patients With Chronic Kidney Disease Based on MRI-FFR
Source: ClinicalTrials.gov · Last updated 23 Sept 2026
Brief summary (registry, in English)
This is a single-center, observational cohort study aiming to validate the diagnostic value of MRI-FF in identifying osteoporosis and sarcopenia in patients with chronic kidney disease (CKD). A total of 868 participants, including 434 CKD patients and 434 non-CKD controls, will be enrolled at Beijing Jishuitan Hospital. All subjects will undergo MRI-FF scans of the lumbar spine and thigh to assess bone mineral density and muscle fat fraction. The primary objective is to evaluate the correlation between MRI-FF parameters and conventional diagnostic criteria for osteoporosis and sarcopenia, as well as to determine the optimal cut-off values for early detection. The study duration is from March 2026 to December 2028.
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 868 (estimated)
- First submitted
- 8 Jun 2026
- Start date
- 28 Jun 2026
- Primary completion date
- 1 Dec 2028
- Lead sponsor
- Capital Medical University
- Diseases
- Chronic kidney disease, Osteoporosis
- NCT number
- NCT07645794
What you commit to
- Study type: Observational
- Planned participants: 868
- From 28 Jun 2026 to the primary completion date, 1 Dec 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Contraindications to MRI (e.g., pacemaker, metal implants, severe claustrophobia).
- Current use of anti-osteoporotic drugs (e.g., bisphosphonates, teriparatide).
Other illness
- History of primary bone metabolic disorders (e.g., osteoporosis, hyperparathyroidism) unrelated to CKD.
- Inability to cooperate with the scan due to cognitive impairment or severe illness.
Other
- Severe lower limb deformity or amputation affecting thigh muscle assessment.
Who the study is looking for
- Age between 18 and 80 years old.
- Able to understand and sign the informed consent form.
- Able to complete MRI-FF scans of the lumbar spine and thigh.
- For CKD group: Confirmed diagnosis of chronic kidney disease (eGFR \< 60 mL/min/1.73m² for ≥3 months).
- For control group: No history of chronic kidney disease and normal renal function.
Age in the registry: 18 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Nephrology Department of Beijing Jishuitan Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.