NCT07646873Not yet recruiting
PET-Enabled Dual-Energy CT in Multiple Myeloma
PET-enabled Dual-energy CT for Oncological Applications
Source: ClinicalTrials.gov · Last updated 15 Jun 2026
Brief summary (registry, in English)
This pilot study will evaluate a new imaging method called PET-enabled dual-energy CT for measuring bone and soft-tissue composition in bone marrow. The study will enroll adults with multiple myeloma who are scheduled to receive CAR T-cell therapy and healthy adult participants. All participants will undergo research imaging with dynamic 18F-FDG PET/CT and X-ray dual-energy CT. Participants with multiple myeloma will have imaging before CAR T-cell therapy and again after therapy. Healthy participants will have one imaging visit. The main goal is to compare bone and soft-tissue fraction measurements from PET-enabled dual-energy CT with measurements from standard X-ray dual-energy CT. The study will also explore whether corrected PET measurements are associated with bone marrow measurable residual disease, treatment response, and CAR T-cell therapy toxicities in participants with multiple myeloma. This study is not expected to provide direct medical benefit to participants. The information learned may help improve future PET/CT imaging methods for cancer evaluation.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 45 (estimated)
- First submitted
- 9 Jun 2026
- Start date
- Jul 2026
- Primary completion date
- Aug 2030
- Lead sponsor
- University of California, Davis
- Diseases
- Multiple myeloma
- NCT number
- NCT07646873
What you commit to
- Study type: Interventional
- Planned participants: 45
- From Jul 2026 to the primary completion date, Aug 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Pregnant or breast-feeding (due to risks of ionizing radiation; urine pregnancy test will be administered prior to start of each PET/CT session for all participants between 18 to 60 years old who are able to get pregnant, unless documented hysterectomy or bilateral ovarian removal is available)
- Concurrent or prior enrollment in a separate research study involving a PET scan performed within the last 12 months for research purposes only. That is, PET scans are not performed as part of a patient's treatment plan (e.g. standard of care, therapeutic purposes, or clinical care) and the research study did not intend to provide therapeutic benefit to the patient.
Other illness
- Self-reported history of dysphoria or anxiety in closed spaces
- Any condition that would prevent the understanding or rendering of informed consent.
Lab values
- Blood glucose greater than 200 as assessed by fingerstick method before injection of 18F-FDG
Other
- Body weight \>240 kg due to limitations of the scanner bed
- Prisoners
- Any comorbidity that, in the opinion of the investigator, could compromise protocol objectives.
Who the study is looking for
- For all research participants:
- Adults (age ≥ 18 years old)
- Ability to understand and willingness to sign an informed consent form
- Ability to adhere to the study visit schedule and other protocol requirements.
- Willing and able to fast for at least 6 hours before and for the duration of the scan
- No strenuous exercise for 24 hours prior to being scanned
- Willing to lie on the scanner bed for up to 60 minutes
- For healthy volunteers only:
- Free of history of cardiovascular, inflammatory, infections or metabolic diseases that would result in changes in bone marrow.
- For cancer patients only:
- Patients with multiple myeloma who are planned to receive CAR T-cell therapy with any FDA-approved product, including Idecel and Ciltacel. Patients with prior chemo-immunotherapy are permitted.
- Able to undergo bone marrow aspirate/biopsy procedure
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UC Davis EXPLORER Molecular Imaging Center Coordinator of this site? Confirm its status | Sacramento | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.