NCT07646977Recruiting
CORonary Thrombus Modification to Prevent MIcrovascular Damage in Patients With ST-segment Elevation Myocardial Infarction (The CORMI Trial)
Source: ClinicalTrials.gov · Last updated 2 Sept 2026
Brief summary (registry, in English)
The aim of this study is to evaluate the effects of coronary thrombus modification on preventing the microvascular damage associated with primary percutaneous coronary intervention (PCI), and to limit the associated myocardial damage assessed by myocardial salvage index after 3 months. Furthermore, the project will evaluate coronary microvascular damage assessed invasively using both continuous and bolus thermodilution before and after stent implantation. In addition, the project will evaluate the diagnostic ability and associations of pre-stenting invasive physiological measurement to cardiac magnetic resonance imaging measurements.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 8 Jun 2026
- Start date
- Jul 2026
- Primary completion date
- Mar 2029
- Lead sponsor
- Odense University Hospital
- Diseases
- Coronary artery disease
- NCT number
- NCT07646977
What you commit to
- Study type: Interventional
- Planned participants: 100
- From Jul 2026 to the primary completion date, Mar 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- CMR contraindications (estimated glomerular filtration rate \< 30 mL/min, magnetic or mechanically activated implants, or any prior metal implants, severe claustrophobia)
Other illness
- Known asthma or severe chronic obstructive pulmonary disease
- Expected inability to perform physiological measurements (due to severely tortuous arteries, ostial disease or very distal disease),
Age
- Age \< 18 years or inability to provide informed consent
Other
- Life expectancy of \< 12 months
- Hemodynamically instability
- Pregnancy or breastfeeding
- Expected to or unavoidable to use thrombectomy
Who the study is looking for
- ST-elevation at the J-junction in a minimum of two contiguous ECG leads with a minimum of ≥ 0.1 mV in all leads, except for V2 and V3 (which required ≥ 0.2 for men ≥ 40 years old, ≥ 0.25 in men \< 40 years old, or ≥ 0.15 mV for all women) or new left bundle branch
- Admission to hospital within 12 hours of symptom debut
- Angiographic signs of a culprit lesion planned to be treated with primary percutaneous coronary intervention
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Odense University Hospital Coordinator of this site? Confirm its status | Odense | Denmark | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.