NCT07647406Completed
Intraseptal and Periodontal Ligament Anaesthesia for Tooth Extraction in Patients With Type 2 Diabetes
Efficacy and Safety of Intraseptal and Periodontal Ligament Anaesthesia for Extraction of Upper Lateral Incisors and Lower First Premolars in Patients With Type 2 Diabetes Mellitus
Source: ClinicalTrials.gov · Last updated 16 Jun 2026
Brief summary (registry, in English)
The goal of this clinical trial is to compare two local anesthesia techniques, intraseptal anesthesia (ISA) and periodontal ligament anesthesia (PLA), in patients with controlled type 2 diabetes mellitus undergoing tooth extraction. The main questions it aims to answer are: Which technique provides more effective local anesthesia for tooth extraction? Do ISA and PLA differ in their effects on blood pressure and heart rate during the procedure? Researchers will compare ISA and PLA to determine which method is more effective and safer in this patient population. Participants will: Receive local anesthesia (ISA or PLA) using articaine with epinephrine delivered with a computer-controlled system Undergo extraction of a maxillary lateral incisor or mandibular first premolar Have blood pressure and heart rate measured before, during, and after anesthesia and extraction
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 120 (actual)
- First submitted
- 9 Jun 2026
- Start date
- 11 Jan 2026
- Primary completion date
- 17 Apr 2026
- Lead sponsor
- University of Business Academy in Novi Sad, Serbia
- Diseases
- Type 2 diabetes
- NCT number
- NCT07647406
What you commit to
- Study type: Interventional
- Participants enrolled: 120
- From 11 Jan 2026 to the primary completion date, 17 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with alcohol or drug dependence
- Dental treatment within the last 48 hours prior to procedure
Other illness
- Acute periodontal disease at the site of injection
- History of tooth trauma or hypersensitivity in target teeth
- Non-controlled diabetes mellitus (implied, since study includes controlled DM only
Other
- Smokers
- Contraindications to local anesthetics or vasoconstrictors
- Acute dentoalveolar abscess
Who the study is looking for
- Controlled Type 2 diabetes mellitus
- Age 35-77 years
- Patients requiring extraction of maxillary lateral incisors or mandibular first premolars
- Teeth free of acute periodontal disease
- No acute dentoalveolar abscess
- No dental treatment within last 48 hours
- No smoking
- No alcohol or drug dependence
- No contraindications to local anesthetic or vasoconstrictor
Age in the registry: 35 years to 77 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculty of Dentistry in Pančevo, University of Business Academy in Novi Sad Coordinator of this site? Confirm its status | Pančevo | Serbia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.