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NCT07647939Not yet recruiting

Exclusion of Left Atrial Appendage Thrombus in Emergency Department Patients With Atrial Fibrillation Undergoing CT to Assess for Pulmonary Embolus: A Feasibility Study

Source: ClinicalTrials.gov · Last updated 26 Oct 2026

Brief summary (registry, in English)

This study aims to investigate whether a quick, additional CT scan of the heart, performed immediately after a standard CT scan for pulmonary embolism, can effectively detect blood clots in the left atrial appendage (LAA) in patients with atrial fibrillation. Detecting these clots is crucial before certain heart procedures to prevent stroke. Currently, a different, more involved procedure (Transesophageal Echocardiography - TEE) is often used. This study will assess if this additional CT scan is feasible, meaning if it can provide clear enough images to identify LAA clots without needing more contrast dye. The study will involve 60 patients, half receiving an "ungated" CT scan and the other half a "gated" CT scan (timed with their heart rhythm). The results of these scans will not be used for immediate patient care during the study, but rather to evaluate the CT scan technique itself. There is no direct benefit to participants, but the information gained could lead to faster diagnosis and reduced unnecessary testing for future patients.

Status (registry)
Not yet recruiting
Study type
Interventional
Enrollment
60 (estimated)
First submitted
16 Mar 2026
Start date
1 Nov 2026
Primary completion date
30 Apr 2027
Lead sponsor
Northwell Health
NCT number
NCT07647939

What you commit to

  • Study type: Interventional
  • Planned participants: 60
  • From 1 Nov 2026 to the primary completion date, 30 Apr 2027
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Stroke like symptoms
  • Heart rate \<40 or \> 120 bpm (inclusive) or 3rd degree heart block

Other

  • Inability to personally give informed consent
  • Pregnant or breastfeeding individuals
  • ECG criteria for ischemia or infarction
  • Unable to lie flat for at least 10 minutes
  • Unable to follow simple commands
  • Northwell Health Employees.
  • Non-English-speaking patients

Who the study is looking for

  • Patients above 18 years of age years deemed candidates for CT angiography for pulmonary embolism by the primary team on clinical grounds and noted to be in atrial fibrillation at the time.
  • Room air oxygen saturation above 92%
  • Systolic blood pressure above 100 mm Hg
  • Respiratory rate less than 24 breaths/min

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
North Shore University Hospital
Coordinator of this site? Confirm its status
ManhassetUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.