NCT07649538Enrolling by invitation
Mediators of Loin Pain in IgA Nephropathy
LO-PAIgN: Mediators of Loin Pain in Immunoglobulin-A Nephropathy
Source: ClinicalTrials.gov · Last updated 20 Oct 2026
Brief summary (registry, in English)
The goal of this observational study is to learn about loin pain in people with Immunoglobulin A nephropathy (IgAN). The main question it aims to answer is: What changes occur in the kidneys, urine, and blood when people with IgAN experience loin pain? Participants will have MRI scans of their kidneys, provide urine and blood samples, and have their latest kidney function test results reviewed. For participants who experience loin pain, these assessments will be carried out during a pain episode and again when they are pain-free, so the results can be compared.
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 40 (estimated)
- First submitted
- 2 Jun 2026
- Start date
- 13 Oct 2026
- Primary completion date
- 20 Dec 2027
- Lead sponsor
- University of Leicester
- Diseases
- IgA nephropathy
- NCT number
- NCT07649538
What you commit to
- Study type: Observational
- Planned participants: 40
- From 13 Oct 2026 to the primary completion date, 20 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Therapies that interfere with immune-mediation like steroids and complement inhibitors
- Kidney transplant recipients
- Patients with implants that are not MRI-safe (pacemakers, implantable defibrillators, cochlear implants, some shunts, neurostimulators, some aneurysm clips, etc.)
- Cohort B
- Therapies that interfere with immune-mediation like steroids and complement inhibitors
- Kidney transplant recipients
Other illness
- Other renal diseases
- Other renal diseases
- Patients with conditions/implants that are not MRI-compatible (claustrophobia, pacemakers, implantable defibrillators, cochlear implants, some shunts, neurostimulators, some aneurysm clips, etc.)
Other
- Cohort A
- Constant loin pain
- Infrequent loin pain (no pain experienced in the last 6 months)
- Inability to differentiate loin pain from back pain
- Current participation in an interventional study that may affect kidney function
- Patients on dialysis
- Current participation in an interventional study that may affect kidney function
- Patients on dialysis
Who the study is looking for
- Cohort A
- ≥18 years of age at the time of recruitment
- IgAN diagnosis confirmed with a renal biopsy
- Episodic/Intermittent Loin Pain (defined as pain at least once every 6 months)
- Have the capacity to consent to the study Cohort B
- 1\) ≥18 years of age at the time of recruitment 2) IgAN diagnosis confirmed with a renal biopsy 3) No history of loin pain 4) Have the capacity to consent to the study
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospitals of Leicester Coordinator of this site? Confirm its status | Leicester | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.