NCT07649850Withdrawn
Improve Muscle Weakness in Patient With COPD
Aerobic Exercise Combined With Blood Flow Restriction Improves Muscle Strength and Functional Capacity In Patients With Emphysematous COPD: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 21 Oct 2026
Brief summary (registry, in English)
This randomized controlled trial investigated the effects of combining aerobic exercise with blood flow restriction (BFR) training in patients with emphysematous chronic obstructive pulmonary disease (COPD). The study aimed to determine whether adding BFR to aerobic exercise could enhance muscle strength and functional capacity compared with conventional training alone. The findings demonstrated that aerobic exercise combined with BFR significantly improved lower-limb muscle strength, exercise tolerance, and functional performance in patients with emphysematous COPD. These results suggest that BFR-assisted aerobic training may serve as an effective and safe rehabilitation strategy to improve physical function and quality of life in this population.
- Status (registry)
- Withdrawn
- Study type
- Interventional
- Enrollment
- 0 (actual)
- First submitted
- 14 May 2026
- Start date
- 10 Jun 2026
- Primary completion date
- 15 Aug 2026
- Lead sponsor
- Al-Zaytoonah University of Jordan
- Diseases
- COPD
- NCT number
- NCT07649850
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Severe hypoxemia requiring continuous oxygen therapy during exercise.
Other illness
- Acute COPD exacerbation or respiratory infection during the study period.
- Severe cardiovascular diseases (e.g., unstable angina, uncontrolled hypertension, recent myocardial infarction).
- Peripheral vascular disease or contraindications to blood flow restriction (BFR) training.
- Severe musculoskeletal, neurological, or orthopedic disorders limiting exercise performance.
- Cognitive impairment affecting cooperation or informed consent.
- History of deep vein thrombosis or clotting disorders.
Other
- Participation in another structured rehabilitation program during the study period.
Who the study is looking for
- Patients diagnosed with emphysematous chronic obstructive pulmonary disease (COPD).
- Clinically stable COPD patients with no acute exacerbation within the previous 4-6 weeks.
- Mild to moderate disease severity according to GOLD criteria.
- Ability to participate safely in aerobic exercise training.
- Medically stable and cleared by a physician for pulmonary rehabilitation.
- Ability to understand and follow study instructions.
Age in the registry: 50 years to 70 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.